Evidence map›Paper›PMID 30450911›Full record

ArticleJournal of proteome research2019

Cytoscape StringApp: Network Analysis and Visualization of Proteomics Data.

Nadezhda T Doncheva, John H Morris, Jan Gorodkin, Lars J Jensen

Abstract read
In one paragraph

Article in Journal of proteome research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1,340 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
1,340citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1,340 citing papers in PubMed, 3 syntheses or guidelines pooled it.

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1,280 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Nadezhda T DonchevaNovo Nordisk Foundation Center for Protein Research , University of Copenhagen , 2200 Copenhagen N, Denmark.ORCID 0000-0002-8806-6850
John H MorrisResource on Biocomputing, Visualization, and Informatics , University of California , San Francisco , California 94158-2517 , United States.ORCID 0000-0003-0290-7979
Jan GorodkinCenter for Non-Coding RNA in Technology and Health , University of Copenhagen , 1870 Frederiksberg C, Denmark.
Lars J JensenNovo Nordisk Foundation Center for Protein Research , University of Copenhagen , 2200 Copenhagen N, Denmark.ORCID 0000-0001-7885-715X

Funding

TR&D 3 - Network Guided Machine LearningP41GM103504 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI IDEKER, TREY · 2012 to 2024
$17.3M
NIGMS NIH HHS P41 GM103504
6 · The paper itself

Abstract

Protein networks have become a popular tool for analyzing and visualizing the often long lists of proteins or genes obtained from proteomics and other high-throughput technologies. One of the most popular sources of such networks is the STRING database, which provides protein networks for more than 2000 organisms, including both physical interactions from experimental data and functional associations from curated pathways, automatic text mining, and prediction methods. However, its web interface is mainly intended for inspection of small networks and their underlying evidence. The Cytoscape software, on the other hand, is much better suited for working with large networks and offers greater flexibility in terms of network analysis, import, and visualization of additional data. To include both resources in the same workflow, we created stringApp, a Cytoscape app that makes it easy to import STRING networks into Cytoscape, retains the appearance and many of the features of STRING, and integrates data from associated databases. Here, we introduce many of the stringApp features and show how they can be used to carry out complex network analysis and visualization tasks on a typical proteomics data set, all through the Cytoscape user interface. stringApp is freely available from the Cytoscape app store: http://apps.cytoscape.org/apps/stringapp .

Indexed as

Data AnalysisSoftwareComputational BiologyInternetProtein Interaction MapsProteomicsUser-Computer InterfaceCytoscapefunctional enrichmentnetwork analysisnetwork visualizationprotein networksproteomics dataSTRING database

Identifiers

PMID30450911
PMCPMC6800166

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.