Evidence map›Paper›PMID 30450856›Full record

ArticleYonsei medical journal2018

Serum Periostin Levels: A Potential Serologic Marker for Toluene Diisocyanate-Induced Occupational Asthma.

Ji Ho Lee, Sang Ha Kim, Youngwoo Choi, Hoang Kim Tu Trinh, Eun Mi Yang, Ga Young Ban, Yoo Seob Shin, Young Min Ye, Kenji Izuhara, Hae Sim Park

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Yonsei medical journal, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.5field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 6 citations in OpenAlex.

  1. Progress in Occupational Asthma.International journal of environmental research and public health · 2020
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 2 countries.

Ji Ho LeeDepartment of Internal Medicine, Yonsei University Wonju College of Medicine, Wonju, Korea.
Sang Ha KimDepartment of Internal Medicine, Yonsei University Wonju College of Medicine, Wonju, Korea.
Youngwoo ChoiDepartment of Allergy and Clinical Immunology, Ajou University School of Medicine, Suwon, Korea.
Hoang Kim Tu TrinhDepartment of Allergy and Clinical Immunology, Ajou University School of Medicine, Suwon, Korea.
Eun Mi YangDepartment of Allergy and Clinical Immunology, Ajou University School of Medicine, Suwon, Korea.
Ga Young BanDepartment of Pulmonary, Allergy and Critical Care Medicine, Kangdong Sacred Heart Hospital, Hallym University College of Medicine, Seoul, Korea.
Yoo Seob ShinDepartment of Allergy and Clinical Immunology, Ajou University School of Medicine, Suwon, Korea.
Young Min YeDepartment of Allergy and Clinical Immunology, Ajou University School of Medicine, Suwon, Korea.
Kenji IzuharaDivision of Medical Biochemistry, Department of Biomolecular Sciences, Saga Medical School, Saga, Japan.
Hae Sim ParkDepartment of Allergy and Clinical Immunology, Ajou University School of Medicine, Suwon, Korea. hspark@ajou.ac.kr.ORCID https://orcid.org/0000-0003-2614-0303
Ajou University · KRYonsei University · KRHallym University · KRSaga Medical School Hospital · JP

Funding

Korean Society of Occupational Asthma and Lung DiseasesMinistry of Health and Welfare HI14C2628
6 · The paper itself

Abstract

purposeToluene diisocyanate (TDI) is a leading cause of occupational asthma (OA). Periostin is a matricellular protein implicated in type 2 immunity-driven asthma. Its pathogenic role in TDI-OA has not been completely elucidated. The present study was performed to investigate the role of periostin in TDI-OA. MATERIALS AND

methodsSerum periostin levels were measured in subjects with TDI-OA, asymptomatic TDI-exposure controls (AECs), non-occupational asthmatics (NAs), and unexposed normal controls (NCs). To understand the mechanism by which TDI induces periostin production, primary small airway epithelial cells (SAECs) were cultured under stimulation of TDI and neutrophils from asthmatic patients.

resultsFifty-three subjects with TDI-OA, 71 AECs, 67 NAs, and 83 NCs were enrolled. Serum periostin levels were significantly higher in TDI-OA subjects than in AECs (

conclusionThese results suggest that an increased periostin level may contribute to the progression of airway inflammation to remodeling in TDI-exposed workers. A high serum periostin level is a potential serologic marker of the phenotype of TDI-OA.

Indexed as

AdultAsthmaAsthma, OccupationalBiomarkersCase-Control StudiesCell Adhesion MoleculesEndothelial CellsFemaleHumansInflammationMaleNeutrophilsOccupational DiseasesReactive Oxygen SpeciesToluene 2,4-DiisocyanateTransforming Growth Factor beta1BiomarkersCell Adhesion MoleculesPOSTN protein, humanReactive Oxygen SpeciesTGFB1 protein, humanToluene 2,4-DiisocyanateTransforming Growth Factor beta1Diisocyanateneutrophilsoccupational asthmaperiostinreactive oxygen species

Identifiers

PMID30450856
PMCPMC6240562
OpenAlexW2901585193

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.