Evidence map›Paper›PMID 30450838›Full record

ArticleJournal of cellular and molecular medicine2019

Mast cell tetrahydrobiopterin contributes to itch in mice.

Katja Zschiebsch, Caroline Fischer, Annett Wilken-Schmitz, Gerd Geisslinger, Keith Channon, Katrin Watschinger, Irmgard Tegeder

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of cellular and molecular medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.4field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 9 citations in OpenAlex.

  1. Review
  2. Review
  3. Mast cell-derived BH4 is a critical mediator of postoperative pain.bioRxiv : the preprint server for biology · 2023
    Article
  4. Review
  5. Mast cell tetrahydrobiopterin contributes to itch in mice.Journal of cellular and molecular medicine · 2019
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 3 countries.

Katja ZschiebschInstitute of Clinical Pharmacology, Goethe-University Hospital, Frankfurt, Germany.
Caroline FischerInstitute of Clinical Pharmacology, Goethe-University Hospital, Frankfurt, Germany.
Annett Wilken-SchmitzInstitute of Clinical Pharmacology, Goethe-University Hospital, Frankfurt, Germany.
Gerd GeisslingerInstitute of Clinical Pharmacology, Goethe-University Hospital, Frankfurt, Germany.
Keith ChannonDivision of Cardiovascular Medicine, University of Oxford, Oxford, UK.
Katrin WatschingerDivision of Biological Chemistry, Biocenter, Medical University of Innsbruck, Innsbruck, Austria.
Irmgard TegederInstitute of Clinical Pharmacology, Goethe-University Hospital, Frankfurt, Germany.ORCID 0000-0001-7524-8025
Goethe University Frankfurt · DEInnsbruck Medical University · ATUniversity of Oxford · GB

Funding

British Heart Foundation RG/07/003/23133British Heart Foundation RG/12/5/29576British Heart Foundation RG/17/10/32859
6 · The paper itself

Abstract

GTP cyclohydrolase (GCH1) governs de novo synthesis of the enzyme cofactor, tetrahydrobiopterin (BH4), which is essential for biogenic amine production, bioactive lipid metabolism and redox coupling of nitric oxide synthases. Overproduction of BH4 via upregulation of GCH1 in sensory neurons is associated with nociceptive hypersensitivity in rodents, and neuron-specific GCH1 deletion normalizes nociception. The translational relevance is revealed by protective polymorphisms of GCH1 in humans, which are associated with a reduced chronic pain. Because myeloid cells constitute a major non-neuronal source of BH4 that may contribute to BH4-dependent phenotypes, we studied here the contribution of myeloid-derived BH4 to pain and itch in lysozyme M Cre-mediated GCH1 knockout (LysM-GCH1

Indexed as

AnimalsBiopterinsCalciumCell DegranulationChronic PainFemaleGene ExpressionGTP CyclohydrolaseHistamineHumansHydroxychloroquineIntegrasesIon TransportMaleMast CellsMiceBiopterinsCalciumCre recombinaseGCH1 protein, humanGch1 protein, mouseGTP CyclohydrolaseHistamineHydroxychloroquineIntegraseslysozyme M, mouseMuramidaseNitric Oxidep-Methoxy-N-methylphenethylaminesapropterinSerotonininflammationnitric oxidepainpruritusredox signallingsensory neuronstetrahydrobiopterin

Identifiers

PMID30450838
PMCPMC6349351
OpenAlexW2901845669

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.