Evidence map›Paper›PMID 30450671›Full record

Observational studyBritish journal of haematology2019

Mature outcomes and prognostic indices in diffuse large B-cell lymphoma in Malawi: a prospective cohort.

Matthew S Painschab, Edwards Kasonkanji, Takondwa Zuze, Bongani Kaimila, Tamiwe Tomoka, Richard Nyasosela, Ruth Nyirenda, Bal M Dhungel, Maurice Mulenga, Maria Chikasema and 11 more

Abstract readObservational Study
In one paragraph

Observational study in British journal of haematology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Trial
  3. Article
  4. Review
  5. Article
  6. Article
  7. A Single Centre Retrospective Cohort Analysis of HIV Associated Lymphoma from Northern India.Indian journal of hematology & blood transfusion : an official journal of Indian Society of Hematology and Blood Transfusion · 2025
    Article
  8. Review
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Observational
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors.

Matthew S PainschabUNC Project-Malawi, Lilongwe, Malawi.ORCID 0000-0001-9175-7436
Edwards KasonkanjiUNC Project-Malawi, Lilongwe, Malawi.
Takondwa ZuzeUNC Project-Malawi, Lilongwe, Malawi.ORCID 0000-0003-3780-0207
Bongani KaimilaUNC Project-Malawi, Lilongwe, Malawi.
Tamiwe TomokaUNC Project-Malawi, Lilongwe, Malawi.
Richard NyasoselaKamuzu Central Hospital, Lilongwe, Malawi.
Ruth NyirendaKamuzu Central Hospital, Lilongwe, Malawi.
Bal M DhungelUNC Project-Malawi, Lilongwe, Malawi.
Maurice MulengaKamuzu Central Hospital, Lilongwe, Malawi.
Maria ChikasemaUNC Project-Malawi, Lilongwe, Malawi.
Blessings TeweteUNC Project-Malawi, Lilongwe, Malawi.
Asekanadziwa MtangwanikaUNC Project-Malawi, Lilongwe, Malawi.
Sarah ChiyoyolaUNC Project-Malawi, Lilongwe, Malawi.
Wilberforce MhangoUNC Project-Malawi, Lilongwe, Malawi.
Fred ChimzimuUNC Project-Malawi, Lilongwe, Malawi.
Coxcilly KampaniUNC Project-Malawi, Lilongwe, Malawi.
Robert KrysiakUNC Project-Malawi, Lilongwe, Malawi.
Thomas C SheaUniversity of North Carolina, Chapel Hill, NC, USA.
Nathan D MontgomeryUniversity of North Carolina, Chapel Hill, NC, USA.
Yuri FedoriwUniversity of North Carolina, Chapel Hill, NC, USA.
Satish GopalUNC Project-Malawi, Lilongwe, Malawi.

Funding

Consortium for Advancing Management and Prevention of Cancer in People with HIVUM1CA121947 · NCI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Joseph A. Sparano · 2015 to 2026
$253.7M
Virology Research Program (Program 4)P30CA016086 · NCI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Deborah F. Tate · 1985 to 2026
$201.5M
University of Southern CaliforniaU01CA121947 · NCI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI MITSUYASU, RONALD T. · 2006 to 2014
$54.7M
UJMT – ORWH – Gazzetta, Issa-BoubeD43TW009340 · FIC · UNIV OF NORTH CAROLINA CHAPEL HILL · PI William Checkley, Benjamin H. Chi · 2017 to 2026
$14.8M
SUPPORTING THE SCALE-UP HIGH QUALITY HIV CARE AND TREATMENT PROGRAMS IN MALAWI U2GPS001965 · PS · UNIVERSITY OF MALAWI · PI KAMIZA, DR. STEVE · 2009 to 2014
$12.9M
Project 3U54CA190152 · NCI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI DAMANIA, BLOSSOM A, GOPAL, SATISH · 2014 to 2019
$4.2M
Developing a clinical cohort of histopathologically characterized lymphomaK01TW009488 · FIC · UNIV OF NORTH CAROLINA CHAPEL HILL · PI GOPAL, SATISH · 2012 to 2016
$701k
Planning for a National Non-Communicable Disease Center of Research ExcellenceP20CA210285 · NCI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI GOPAL, SATISH · 2016 to 2017
$517k
Molecular profiling of HIV-associated lymphoma in the US and MalawiR21CA180815 · NCI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI GOPAL, SATISH · 2013 to 2014
$341k
FIC NIH HHS D43 TW009340FIC NIH HHS K01 TW009488NCI NIH HHS L30 CA233709NCI NIH HHS P20 CA210285NCI NIH HHS P30 CA016086NCI NIH HHS R21 CA180815NCI NIH HHS U01 CA121947NCI NIH HHS U54 CA190152NCI NIH HHS UM1 CA121947
6 · The paper itself

Abstract

Outcomes for diffuse large B-cell lymphoma (DLBCL) in sub-Saharan Africa (SSA) are poorly described. We report mature data from one of the first prospective SSA cohorts. Patients aged ≥18 years with DLBCL were enrolled in Malawi 2013-2017. Participants were treated with CHOP (cyclophosphamide, doxorubicin, vincristine, prednisone) chemotherapy and concurrent antiretroviral therapy (ART) if positive for human immunodeficiency virus (HIV+). Eighty-six participants (mean age 47 years, standard deviation 13) were enrolled: 54 (63%) were male and 51 (59%) were HIV+, of whom 34 (67%) were on ART at DLBCL diagnosis. Median CD4 count was 0·113 cells × 10

Indexed as

Antineoplastic Combined Chemotherapy ProtocolsAnti-Retroviral AgentsHIV-1HIV SeropositivityLymphoma, Large B-Cell, DiffuseAdultAgedCyclophosphamideDisease-Free SurvivalDoxorubicinHumansMalawiMiddle AgedPrednisoneProspective StudiesSurvival RateAnti-Retroviral AgentsCyclophosphamideDoxorubicinPrednisoneVincristinechemotherapydiffuse large B-cell lymphomahuman immunodeficiency virusprognosissub-Saharan Africa

Identifiers

PMID30450671
PMCPMC6340743

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.