Evidence map›Paper›PMID 30450565›Full record

ReviewImmunology2019

Transcriptional control of natural killer cell differentiation.

Marc Brillantes, Aimee M Beaulieu

Open access · bronzeAbstract readReview
In one paragraph

Review in Immunology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
0.8field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 27 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Review
  8. Article
  9. Article
  10. Article
  11. Memory and Memory-Like NK Cell Responses to Microbial Pathogens.Frontiers in cellular and infection microbiology · 2020
    Review
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Marc BrillantesRutgers Graduate School of Biomedical Sciences, Rutgers - The State University of New Jersey, Newark, NJ, USA.
Aimee M BeaulieuCenter for Immunity and Inflammation, New Jersey Medical School, Rutgers Biomedical and Health Sciences, Rutgers - The State University of New Jersey, Newark, NJ, USA.ORCID 0000-0002-7301-0002
Rutgers, The State University of New Jersey · US

Funding

Birc5 as a regulator of NK cell development and immune functionR01HL139818 · NHLBI · RUTGERS BIOMEDICAL AND HEALTH SCIENCES · PI BEAULIEU, AIMEE MELISSA · 2019 to 2023
$1.9M
Program in Infection, Immunity and InflammationT32AI125185 · NIAID · RBHS-NEW JERSEY MEDICAL SCHOOL · PI SALGAME, PADMINI · 2016 to 2020
$747k
Regulation of innate lymphocyte function by Zbtb32K22AI116802 · NIAID · RBHS-NEW JERSEY MEDICAL SCHOOL · PI BEAULIEU, AIMEE MELISSA · 2016 to 2017
$270k
NHLBI NIH HHS R01 HL139818NIAID NIH HHS K22 AI116802NIAID NIH HHS T32 AI125185NIH-NIAID T32 AI1125185-02
6 · The paper itself

Abstract

Natural killer (NK) cells are highly specialized cytotoxic lymphocytes that provide protection against pathogens and malignant cells. They develop from common lymphoid progenitors via a multi-stage lineage commitment and differentiation process that gives rise to mature NK cells with potent cytotoxic functionality. Although generally considered cells of the innate immune system, recent studies have demonstrated that NK cells have the capacity to mount immune responses with features of adaptive immunity, including robust antigen-specific clonal-like expansion and the generation of long-lived memory cells that mediate enhanced recall responses. Here, we discuss specific transcription factors that have been shown to commonly and uniquely regulate NK cell development and effector and memory responses in experimental mouse models.

Indexed as

Immunity, CellularImmunity, InnateImmunologic MemoryModels, ImmunologicalAnimalsHumansKiller Cells, NaturalMiceTranscription, Geneticdevelopmentepigeneticsmemorytranscription factors

Identifiers

PMID30450565
PMCPMC6329199
OpenAlexW2901070965

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.