Evidence map›Paper›PMID 30450473›Full record

ArticleKidney international reports2018

Multicenter Study Evaluating Intrarenal Oxygenation and Fibrosis Using Magnetic Resonance Imaging in Individuals With Advanced CKD.

Pottumarthi V Prasad, Wei Li, Dominic S Raj, James Carr, Maria Carr, Jon Thacker, Lu-Ping Li, Chi Wang, Stuart M Sprague, Joachim H Ix and 9 more

Registry-linked trialAbstract read
In one paragraph

Article in Kidney international reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07175051 (Targeting the Pathophysiology of Sickle Cell-Related Kidney Disease Using the SGLT2 Inhibitors, Empagliflozin), which is not on this map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07175051 phase2recruitingnot on this mapstarted 2026, after this paper: background citation

Targeting the Pathophysiology of Sickle Cell-Related Kidney Disease Using the SGLT2 Inhibitors, Empagliflozin

TypeinterventionalSponsorUniversity of Illinois at ChicagoRan2026 to 2030Enrolled20ConditionsSickle Cell Anemia (HbSS, or HbSβ-thalassemia0), AlbuminuriaArmsEmpagliflozin (oral)
3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. First Experience with [Diagnostics (Basel, Switzerland) · 2026
    Article
  2. Article
  3. Review
  4. Review
  5. Article
  6. Article
  7. Noninvasive assessment of renal fibrosis by magnetic resonance imaging and ultrasound techniques.Translational research : the journal of laboratory and clinical medicine · 2019
    Review
  8. Article
  9. Observational
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Pottumarthi V PrasadNorthShore University HealthSystem, Evanston, Illinois, USA.
Wei LiNorthShore University HealthSystem, Evanston, Illinois, USA.
Dominic S RajGeorge Washington University School of Medicine and Health Sciences, Washington, DC, USA.
James CarrNorthwestern University Feinberg School of Medicine, Chicago, Illinois, USA.
Maria CarrNorthwestern University Feinberg School of Medicine, Chicago, Illinois, USA.
Jon ThackerNorthShore University HealthSystem, Evanston, Illinois, USA.
Lu-Ping LiNorthShore University HealthSystem, Evanston, Illinois, USA.
Chi WangNorthShore University HealthSystem, Evanston, Illinois, USA.
Stuart M SpragueNorthShore University HealthSystem, Evanston, Illinois, USA.
Joachim H IxUniversity of California San Diego School of Medicine, La Jolla, California, USA.
Michel ChoncholUniversity of Colorado Denver School of Medicine, Aurora, Colorado, USA.
Geoffrey BlockDenver Nephrology, Denver, Colorado, USA.
Alfred K CheungUniversity of Utah School of Medicine, Salt Lake City, Utah, USA.
Kalani RaphaelUniversity of Utah School of Medicine, Salt Lake City, Utah, USA.
Jennifer GassmanCleveland Clinic, Cleveland, Ohio, USA.
Myles WolfDuke University School of Medicine, Durham, North Carolina, USA.
Linda F FriedUniversity of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.
Tamara IsakovaNorthwestern University Feinberg School of Medicine, Chicago, Illinois, USA.
CKD Optimal Management with BInders and NicotinamidE (COMBINE) study group

Funding

Data Coordinating Center for Pilot Studies of Candidate Therapies for CKDU01DK099877 · NIDDK · CLEVELAND CLINIC LERNER COM-CWRU · PI GASSMAN, JENNIFER J · 2013 to 2018
$5.5M
Impact of phosphate and FGF23 reduction on intermediate end points in CKDR01DK102438 · NIDDK · NORTHWESTERN UNIVERSITY AT CHICAGO · PI ISAKOVA, TAMARA · 2014 to 2018
$3.0M
A Novel Approach to Phosphorus Lowering in Patients with Chronic Kidney DiseaseU01DK097093 · NIDDK · VETERANS MEDICAL RESEARCH FDN/SAN DIEGO · PI IX, JOACHIM H · 2013 to 2017
$2.5M
Longitudinal changes in the intra-renal oxygenation by BOLD MRI in patients withR01DK093793 · NIDDK · ENDEAVOR HEALTH CLINICAL OPERATIONS · PI PRASAD, POTTUMARTHI V · 2012 to 2016
$2.3M
Pilot Studies Targeting Mineral Metabolism in CKDU01DK099930 · NIDDK · NORTHWESTERN UNIVERSITY AT CHICAGO · PI ISAKOVA, TAMARA · 2013 to 2018
$1.8M
Anti-inflammatory Therapy in Diabetic CKDU01DK099924 · NIDDK · GEORGE WASHINGTON UNIVERSITY · PI RAJ, DOMINIC S · 2013 to 2018
$1.8M
Oral Sodium Bicarbonate to Slow Chronic Kidney Disease ProgressionU01DK099933 · NIDDK · UNIVERSITY OF UTAH · PI CHEUNG, ALFRED K, RAPHAEL, KALANI LUKELA · 2013 to 2018
$1.5M
Quantitative renal oxygenation assessment with compartment specific calibrationF31HL123360 · NHLBI · NORTHWESTERN UNIVERSITY · PI THACKER, JON MATTHEW · 2015 to 2016
$70k
NHLBI NIH HHS F31 HL123360NIDDK NIH HHS R01 DK093793NIDDK NIH HHS R01 DK102438NIDDK NIH HHS U01 DK097093NIDDK NIH HHS U01 DK099877NIDDK NIH HHS U01 DK099924NIDDK NIH HHS U01 DK099930NIDDK NIH HHS U01 DK099933
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Identifiers

PMID30450473
PMCPMC6224659

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.