Evidence map›Paper›PMID 30450466›Full record

ArticleKidney international reports2018

Augmented Cardiopulmonary Baroreflex Sensitivity in Intradialytic Hypertension.

Sook H Park, Ida T Fonkoue, Yunxiao Li, Dana R DaCosta, Holly R Middlekauff, Jeanie Park

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Kidney international reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
0.3field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 10 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Article
  5. Article
  6. Intradialytic hypertension: epidemiology and pathophysiology of a silent killer.Hypertension research : official journal of the Japanese Society of Hypertension · 2022
    Review
  7. Review
  8. Cerebral blood flow regulation in end-stage kidney disease.American journal of physiology. Renal physiology · 2020
    Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Sook H ParkRenal Division, Department of Medicine, Emory University School of Medicine, Atlanta, Georgia, USA.
Ida T FonkoueRenal Division, Department of Medicine, Emory University School of Medicine, Atlanta, Georgia, USA.
Yunxiao LiDepartment of Biostatistics and Bioinformatics, Rollins School of Public Health, Emory University, Atlanta, Georgia, USA.
Dana R DaCostaRenal Division, Department of Medicine, Emory University School of Medicine, Atlanta, Georgia, USA.
Holly R MiddlekauffDivision of Cardiology, Department of Medicine, David Geffen School of Medicine at University of California Los Angeles, Los Angeles, California, USA.
Jeanie ParkRenal Division, Department of Medicine, Emory University School of Medicine, Atlanta, Georgia, USA.
Emory University · USUniversity of California, Los Angeles · USVeterans Health Administration · US

Funding

Neurovascular Regulation During Exercise In Humans With Chronic Kidney DiseaseR01HL135183 · NHLBI · EMORY UNIVERSITY · PI Jeanie Park · 2017 to 2026
$5.4M
Mechanisms of Sympathetic Overactivity in Post-traumatic Stress DisorderI01CX001065 · VA · VETERANS HEALTH ADMINISTRATION · PI PARK, JEANIE · 2015 to 2024
–
CSRD VA I01 CX001065NHLBI NIH HHS R01 HL135183
6 · The paper itself

Abstract

introductionEnd-stage renal disease (ESRD) patients with a paradoxical increase in blood pressure (BP) during hemodialysis (HD), termed intradialytic hypertension (ID-HTN), are at significantly increased risk for mortality and adverse cardiovascular events. ID-HTN affects up to 15% of all HD patients, and the pathophysiologic mechanisms remain unknown. We hypothesized that ESRD patients prone to ID-HTN have heightened volume-sensitive cardiopulmonary baroreflex sensitivity (BRS) that leads to exaggerated increases in sympathetic nervous system (SNS) activation during HD.

methodsWe studied ESRD patients on maintenance HD with ID-HTN (n = 10) and without ID-HTN (controls, n = 12) on an interdialytic day, 24 to 30 hours after their last HD session. We measured continuous muscle sympathetic nerve activity (MSNA), beat-to-beat arterial BP, and electrocardiography (ECG) at baseline, and during graded lower body negative pressure (LBNP). Low-dose LBNP isolates cardiopulmonary BRS, whereas higher doses allow assessment of physiologic responses to orthostatic stress.

resultsThe ID-HTN patients had significantly higher pre- and post-HD BP, and greater interdialytic fluid weight gain compared to controls. There was a significantly greater increase in MSNA burst incidence (

conclusionPatients with ID-HTN have augmented cardiopulmonary BRS that may contribute to increased SNS activation and BP response during HD.

Indexed as

baroreflexend-stage renal diseasehemodialysissympathetic activity

Identifiers

PMID30450466
PMCPMC6224617
OpenAlexW2885846061

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.