Evidence map›Paper›PMID 30450459›Full record

ArticleKidney international reports2018

Progression of Medial Arterial Calcification in CKD.

Shumila Manzoor, Syed Ahmed, Arshad Ali, Kum Hyun Han, Ioannis Sechopoulos, Ansley O'Neill, Baowei Fei, W Charles O'Neill

Open access · goldAbstract read
In one paragraph

Article in Kidney international reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed, 1 pooled it
3.5field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 1 synthesis or guideline pooled it, 40 citations in OpenAlex.

  1. Pooled it
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  3. Review
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  7. Article
  8. Article
  9. Review
  10. Review
  11. Epidermal growth factor receptor inhibition prevents vascular calcifying extracellular vesicle biogenesis.American journal of physiology. Heart and circulatory physiology · 2023
    Article
  12. Review
  13. Catalysis-Independent ENPP1 Protein Signaling Regulates Mammalian Bone Mass.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2022
    Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Regulatory Role of Sex Hormones in Cardiovascular Calcification.International journal of molecular sciences · 2021
    Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 2 countries.

Shumila ManzoorRenal Division, Department of Medicine, Emory University School of Medicine, Atlanta, Georgia, USA.
Syed AhmedRenal Division, Department of Medicine, Emory University School of Medicine, Atlanta, Georgia, USA.
Arshad AliRenal Division, Department of Medicine, Emory University School of Medicine, Atlanta, Georgia, USA.
Kum Hyun HanRenal Division, Department of Medicine, Emory University School of Medicine, Atlanta, Georgia, USA.
Ioannis SechopoulosDepartment of Radiology and Imaging Sciences, Emory University School of Medicine, Atlanta, Georgia, USA.
Ansley O'NeillRenal Division, Department of Medicine, Emory University School of Medicine, Atlanta, Georgia, USA.
Baowei FeiDepartment of Radiology and Imaging Sciences, Emory University School of Medicine, Atlanta, Georgia, USA.
W Charles O'NeillRenal Division, Department of Medicine, Emory University School of Medicine, Atlanta, Georgia, USA.
Emory University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionMedial arterial calcification is common in chronic kidney disease (CKD) and portends poor clinical outcomes, but its progression relative to the severity of CKD and the role of other risk factors is unknown because of the lack of reliable quantification.

methodsCalcification of breast arteries detected by mammography, which is exclusively medial and correlates with medial calcification in peripheral arteries and with cardiovascular outcomes, was used to measure the progression of medial arterial calcification in women with CKD and end-stage renal disease (ESRD). Measurements showed intra- and interobserver correlations of 0.98, an interstudy variability of 8% to 11%, and a correlation with computed tomographic measurements of 0.92.

resultsProgression of calcification was measured in 60 control subjects (estimated glomerular filtration rate (eGFR) ≥ 90 ml/min per 1.73 m

conclusionMammography is a convenient and reliable method to measure the progression of medial arterial calcification. Progression does not increase until advanced stages of CKD, accelerates markedly in ESRD, and returns to control rates after kidney transplantation. Diabetes significantly increases progression in CKD and ESRD.

Indexed as

diabetesESRDmammographyvascular calcification

Identifiers

PMID30450459
PMCPMC6224661
OpenAlexW2883936128

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.