Evidence map›Paper›PMID 30450383›Full record

ArticleNeurobiology of stress2018

The social defeat/overcrowding murine psychosocial stress model results in a pharmacologically reversible body weight gain but not depression - related behaviours.

Ryan J Keenan, Jacky Chan, Paul S Donnelly, Kevin J Barnham, Laura H Jacobson

Open access · goldAbstract read
In one paragraph

Article in Neurobiology of stress, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
0.4field-weighted citation impact, top 45% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it, 13 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Ryan J KeenanDepartment of Pharmacology and Therapeutics, The University of Melbourne, Parkville, Victoria, 3010, Australia.
Jacky ChanFlorey Institute of Neuroscience and Mental Health, Parkville, Victoria, 3010, Australia.
Paul S DonnellySchool of Chemistry, The University of Melbourne, Parkville, Victoria, 3010, Australia.
Kevin J BarnhamDepartment of Pharmacology and Therapeutics, The University of Melbourne, Parkville, Victoria, 3010, Australia.
Laura H JacobsonDepartment of Pharmacology and Therapeutics, The University of Melbourne, Parkville, Victoria, 3010, Australia.
The University of Melbourne · AUFlorey Institute of Neuroscience and Mental Health · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Depression is a highly prevalent psychiatric disorder, yet its etiology is not well understood. The validation of animal models is therefore a critical step towards advancing knowledge about the neurobiology of depression. Psychosocial stress has been promoted as a prospective animal model of depression, however, different protocols exist with variable responses, and further investigations are therefore required. We aimed to characterise the behavioural and body weight responses to the social defeat/overcrowding (SD/OC) model and to explore the effects of the antidepressant fluoxetine and the peroxynitrite scavenger, Cu

Indexed as

CuII(atsm)DepressionFluoxetinePsychosocial stressSocial defeatWeight gain

Identifiers

PMID30450383
PMCPMC6234278
OpenAlexW2893257545

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.