ReviewNeurobiology of stress2018
Stress reactivity and the developmental psychopathology of adolescent substance use.
Review in Neurobiology of stress, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
32 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Neuroscience-informed classification of prevention interventions in substance use disorders: An RDoC-based approach.Neuroscience and biobehavioral reviews · 2024Pooled it
- The brain in social context: A systematic review of substance use and social processing from adolescence to young adulthood.Developmental cognitive neuroscience · 2022Pooled it
- Behavioral Impaired Control over Alcohol: Comparing Self-Medication and Behavioral Economic Models with the Interacting Effects of Acute Stress, Chronic Stress with Physical Neglect History, and Sex Assigned at Birth.Behavioral sciences (Basel, Switzerland) · 2026Article
- Adverse Childhood Experiences Underlie Race-Related Differences in Neural Reactivity to Stress.Behavioural neurology · 2026Article
- Examining polygenic scores for depression, depressive symptoms from childhood to adolescence, and adolescent substance use in a diverse sample: The moderating impact of a family-centered intervention.Development and psychopathology · 2025Article
- Post-Heroin Post-Traumatic Stress Disorder Spectrum: Heroin Addiction as a Generator of Trauma Sensitisation in Everyday Life: A Perspective Review.Journal of clinical medicine · 2025Article
- Fueling the Cycle: Attachment, Cognition, and Emotion in Substance-Using Incarcerated Young Adults.Clinical neuropsychiatry · 2025Article
- Racial Differences in Biopsychosocial Pathways to Tobacco and Marijuana Use Among Youth.Journal of racial and ethnic health disparities · 2025Article
- Patterns of Respiration Rate Reactivity in Response to a Cognitive Stressor Associate With Self-Reported Mental Health Outcomes.Psychological reports · 2025Article
- Parental Alcohol Use Predicts Neural Emotion Reactivity and Substance Use Intentions in Early Adolescence.The Journal of early adolescence · 2025Article
- Substance Use is Associated With College Students' Acute Parasympathetic Nervous System Responses to Challenge.Stress and health : journal of the International Society for the Investigation of Stress · 2025Article
- Adolescents' neural responses to their parents' emotions: associations with emotion regulation, internalizing symptoms, and substance use.Social cognitive and affective neuroscience · 2024Article
- Sex differences in the prospective association of excessively long reaction times and hazardous cannabis use at six months.Addictive behaviors reports · 2024Article
- Self-esteem mediates child abuse predicting adulthood anxiety, depression, and substance use symptoms 18 years later.Journal of affective disorders · 2024Article
- Associations between emotional reactivity to stress and adolescent substance use: Differences by sex and valence.Stress and health : journal of the International Society for the Investigation of Stress · 2024Article
- Stress and substance use disorders: risk, relapse, and treatment outcomes.The Journal of clinical investigation · 2024Review
- Childhood maltreatment and substance use risk: A moderated mediation model of autonomic reactivity and distress tolerance.Child abuse & neglect · 2024Article
- Sex differences in neural response to an acute stressor in individuals with an alcohol use disorder.Alcohol, clinical & experimental research · 2024Article
- Underreporting of implementation strategies and barriers in physical activity interventions for young people at risk of problematic substance use: a brief report.Implementation science communications · 2024Article
- Neuroendocrine mechanisms in the links between early life stress, affect, and youth substance use: A conceptual model for the study of sex and gender differences.Frontiers in neuroendocrinology · 2024Review
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
Adolescence represents a period of risk for initiation of substance use and the development of substance use disorders (SUDs). In addition, during adolescence, there is rapid development of stress reactivity systems. This paper describes a conceptual model of the role of stress reactivity in the development of substance use in adolescence. It is proposed that some children develop maladaptive patterns of emotional, physiological, and neural reactivity to stressful situations that are either too high or too low and that their patterns of reactivity interact with increased stressful life events during adolescence to lead to potential for substance use and SUDs. In one pathway, youth develop a heightened reactivity to stress, which leads to high negative emotion and using substances to cope. In a second pathway, youth develop a blunted reactivity to stress, which leads to chronic under-arousal and using substances to increase sensation/arousal. We propose that girls may be more likely to take the high-reactivity pathway to substance use and boys may be more likely to take the low-reactivity pathway. We review existing studies of stress reactivity in adolescents, which support our theory that altered stress reactivity is correlated with and, in some cases, predictive of adolescent substance use, with some studies finding high stress reactivity and some finding low stress reactivity to be correlated with increased substance use and SUD risk. Some studies find that the blunted reactivity pathway to substance use occurs particularly for youth from high-risk contexts. Further, some evidence supports the proposed sex differences in stress reactivity pathways. We discuss future directions and implications of these findings for developing and refining developmentally-sensitive stress reactivity-focused SUD prevention programs.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.