ArticleJournal of pathology informatics2018
Validation of Remote Digital Frozen Sections for Cancer and Transplant Intraoperative Services.
Article in Journal of pathology informatics, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
28 citing papers in PubMed, 3 syntheses or guidelines pooled it, 42 citations in OpenAlex.
- Artificial intelligence applications for pre-implantation kidney biopsy pathology practice: a systematic review.Journal of nephrology · 2022Pooled it
- Technical and Diagnostic Issues in Whole Slide Imaging Published Validation Studies.Frontiers in oncology · 2022Pooled it
- Systematic Review of the Use of Telepathology During Intraoperative Consultation.American journal of clinical pathology · 2020Pooled it
- Mobile device smartphones for intraoperative diagnosis at the University Hospital Trust of Modena/UNIMORE: from validation process to costs analysis.Diagnostic pathology · 2026Article
- Diagnostic Assessment of Deep Learning Algorithms for Frozen Tissue Section Analysis in Women with Breast Cancer.Cancer research and treatment · 2023Article
- The Nomadic Digital Pathologist. Validation of a simple, dual slide scanner with remote reporting for a regional upper gastrointestinal specialist multidisciplinary meeting.Journal of pathology informatics · 2023Article
- Digital pathology implementation in a private laboratory: The CEDAP experience.Journal of pathology informatics · 2023Article
- Validation of Remote Digital Pathology based diagnostic reporting of Frozen Sections from home.Journal of pathology informatics · 2023Article
- Value of a Multidisciplinary Approach in Sinonasal Inverted Papilloma with Extensive Ossification.The American journal of case reports · 2022Article
- Stain normalization in digital pathology: Clinical multi-center evaluation of image quality.Journal of pathology informatics · 2022Article
- An Expandable Informatics Framework for Enhancing Central Cancer Registries with Digital Pathology Specimens, Computational Imaging Tools, and Advanced Mining Capabilities.Journal of pathology informatics · 2022Article
- Validation of portable tablets for transplant pathology diagnosis according to the College of American Pathologists Guidelines.Academic pathology · 2022Article
- Lost in digitization - A systematic review about the diagnostic test accuracy of digital pathology solutions.Journal of pathology informatics · 2022Review
- Integrated digital pathology at scale: A solution for clinical diagnostics and cancer research at a large academic medical center.Journal of the American Medical Informatics Association : JAMIA · 2021Article
- Artificial intelligence for early detection of pancreatic adenocarcinoma: The future is promising.World journal of gastroenterology · 2021Review
- The histopathological diagnosis of atypical meningioma: glass slide versus whole slide imaging for grading assessment.Virchows Archiv : an international journal of pathology · 2021Article
- DPA-ESDIP-JSDP Task Force for Worldwide Adoption of Digital Pathology.Journal of pathology informatics · 2021Article
- Digital Slides as an Effective Tool for Programmed Death Ligand 1 Combined Positive Score Assessment and Training: Lessons Learned from the "Programmed Death Ligand 1 Key Learning Program in Head-and-Neck Squamous Cell Carcinoma".Journal of pathology informatics · 2021Article
- Commentary: The Digital Fate of Glomeruli in Renal Biopsy.Journal of pathology informatics · 2021Article
- Digital Slide Assessment for Programmed Death-Ligand 1 Combined Positive Score in Head and Neck Squamous Carcinoma: Focus on Validation and Vision.Frontiers in artificial intelligence · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
17 authors at 9 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionWhole-slide imaging (WSI) technology can be used for primary diagnosis and consultation, including intraoperative (IO) frozen section (FS). We aimed to implement and validate a digital system for the FS evaluation of cancer and transplant specimens following recommendations of the College of American Pathologists. MATERIALS AND
methodsFS cases were routinely scanned at ×20 employing the "Navigo" scanner system. IO diagnoses using glass versus digital slides after a 3-week washout period were recorded. Intraobserver concordance was evaluated using accuracy rate and kappa statistics. Feasibility of WSI diagnoses was assessed by the way of sensitivity, specificity, as well as positive and negative predictive values. Participants also completed a survey denoting scan time, time spent viewing cases, preference for glass versus WSI, image quality, interface experience, and any problems encountered.
resultsOf the 125 cases submitted, 121 (436 slides) were successfully scanned including 93 oncological and 28 donor-organ FS biopsies. Four cases were excluded because of failed digitalization due to scanning problems or sample preparation artifacts. Full agreement between glass and digital-slide diagnosis was obtained in 90 of 93 (97%, κ = 0.96) oncology and in 24 of 28 (86%, κ = 0.91) transplant cases. There were two major and one minor discrepancy for cancer cases (sensitivity 100%, specificity 96%) and two major and two minor disagreements for transplant cases (sensitivity 96%, specificity 75%). Average scan and viewing/reporting time were 12 and 3 min for cancer cases, compared to 18 and 5 min for transplant cases. A high diagnostic comfort level among pathologists emerged from the survey.
conclusionsThese data demonstrate that the "Navigo" digital WSI system can reliably support an IO FS service involving complicated cancer and transplant cases.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.