Evidence map›Paper›PMID 30450188›Full record

ArticleJournal of tissue engineering

Equine lung decellularization: a potential approach for in vitro modeling the role of the extracellular matrix in asthma.

Renata Kelly da Palma, Paula Fratini, Gustavo Sá Schiavo Matias, Andressa Daronco Cereta, Leticia Lopes Guimarães, Adriana Raquel de Almeida Anunciação, Luis Vicente Franco de Oliveira, Ramon Farre, Maria Angelica Miglino

Abstract read
In one paragraph

Article in Journal of tissue engineering. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Renata Kelly da PalmaPost Graduate Program in Science of Rehabilitation, University Nove de Julho (UNINOVE), São Paulo, Brazil.ORCID https://orcid.org/0000-0002-4799-0385
Paula FratiniDepartment of Surgery, School of Veterinary Medicine and Animal Science, University of São Paulo, São Paulo, Brazil.
Gustavo Sá Schiavo MatiasDepartment of Surgery, School of Veterinary Medicine and Animal Science, University of São Paulo, São Paulo, Brazil.
Andressa Daronco CeretaDepartment of Surgery, School of Veterinary Medicine and Animal Science, University of São Paulo, São Paulo, Brazil.
Leticia Lopes GuimarãesDepartment of Surgery, School of Veterinary Medicine and Animal Science, University of São Paulo, São Paulo, Brazil.
Adriana Raquel de Almeida AnunciaçãoDepartment of Surgery, School of Veterinary Medicine and Animal Science, University of São Paulo, São Paulo, Brazil.
Luis Vicente Franco de OliveiraMedical School, University Center of Anápolis-UniEVANGELICA, Anápolis, Brazil.
Ramon FarreUnitat Biofísica i Bioenginyeria, Facultat de Medicina i Ciències de la Salut, Universitat de Barcelona, Barcelona, Spain.
Maria Angelica MiglinoDepartment of Surgery, School of Veterinary Medicine and Animal Science, University of São Paulo, São Paulo, Brazil.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Contrary to conventional research animals, horses naturally develop asthma, a disease in which the extracellular matrix of the lung plays a significant role. Hence, the horse lung extracellular matrix appears to be an ideal candidate model for in vitro studying the mechanisms and potential treatments for asthma. However, so far, such model to study cell-extracellular matrix interactions in asthma has not been developed. The aim of this study was to establish a protocol for equine lung decellularization that maintains the architecture of the extracellular matrix and could be used in the future as an in vitro model for therapeutic treatment in asthma. For this the equine lungs were decellularized by sodium dodecyl sulfate detergent perfusion at constant gravitational pressure of 30 cmH

Indexed as

asthmadecellularizedEquine lungextracellular matrixrespiratory diseases

Identifiers

PMID30450188
PMCPMC6236489

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.