ArticleThe open biomedical engineering journal2018
Characterization of the F-box Proteins FBXW2 and FBXL14 in the Initiation of Bone Regeneration in Transplants given to Nude Mice.
Article in The open biomedical engineering journal, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed, 1 citations in OpenAlex.
- Scaffold-Free Bone Regeneration Through Collaboration Between Type IV Collagen and FBXL14.Journal of clinical medicine · 2025Article
- Identification of the key exosomal lncRNAs/mRNAs in the serum during distraction osteogenesis.Journal of orthopaedic surgery and research · 2022Article
- Role of FBXW2 in explant cultures of bovine periosteum-derived cells.BMC research notes · 2021Article
- FBXW2 localizes with osteocalcin in bovine periosteum on culture dishes as visualized by double immunostaining.Heliyon · 2018Article
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Authors and funding
1 author at 1 institution in 1 country.
Funding
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Abstract
backgroundCultured bovine-periosteum-derived cells can form three-dimensional structures on tissue culture dishes without artificial scaffolding material, can induce bone regeneration
objectiveThe aim of this study was to investigate the specific F-box proteins required for bone regeneration by cultured bovine-periosteum-derived cells
methodsIn the present study, periosteum tissue and cultured periosteum-derived cells were cultured for 5 weeks
resultsThe bovine-periosteum-derived cells were observed to form bone shortly after the expression of F-box proteins. After the initial phase of bone formation, the expression of the F-box proteins ceased. FBXW2 was shown to be expressed in the periosteum, but not in cultured periosteum-derived cells. Furthermore, FBXL14 disappeared during bone formation.
conclusionsBone regeneration requires progenitor cells, such as bovine-periosteum-derived cells and the activation of the F-box Proteins FBXW2 and FBXL14, over time the expression of these proteins ceases. Further scientific and clinical trials are needed to investigate how the F-box Proteins can be used therapeutically to treat osteoporosis and osteonecrosis.
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