Evidence map›Paper›PMID 30449893›Full record

ArticleApplied physics letters2018

Synthetic Bessel light needle for extended depth-of-field microscopy.

Jiamiao Yang, Lei Gong, Yuecheng Shen, Lihong V Wang

Abstract read
In one paragraph

Article in Applied physics letters, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Jiamiao YangCaltech Optical Imaging Laboratory, Andrew and Peggy Cherng Department of Medical Engineering, Department of Electrical Engineering, California Institute of Technology, Pasadena, California 91125, USA.ORCID 0000-0003-0006-8411
Lei GongDepartment of Optics and Optical Engineering, University of Science and Technology of China, Hefei, Anhui 230026, China.ORCID 0000-0002-0995-5781
Yuecheng ShenCaltech Optical Imaging Laboratory, Andrew and Peggy Cherng Department of Medical Engineering, Department of Electrical Engineering, California Institute of Technology, Pasadena, California 91125, USA.ORCID 0000-0003-1990-8142
Lihong V WangCaltech Optical Imaging Laboratory, Andrew and Peggy Cherng Department of Medical Engineering, Department of Electrical Engineering, California Institute of Technology, Pasadena, California 91125, USA.

Funding

PHOTON TUNNELING: SHEDDING NEW LIGHT ON BIOMEDICINEDP1EB016986 · NIBIB · WASHINGTON UNIVERSITY · PI WANG, LIHONG · 2012 to 2016
$3.8M
Deep brain photoacoustic tomography at single-neuron resolution using arrays of photonic emitters and high-frequency ultrasound transducersU01NS099717 · NINDS · CALIFORNIA INSTITUTE OF TECHNOLOGY · PI ROUKES, MICHAEL L, SHEPARD, KENNETH L · 2016 to 2018
$3.0M
Safe, rapid & functional pediatric brain imaging using photoacoustic computed tomographyR01NS102213 · NINDS · CALIFORNIA INSTITUTE OF TECHNOLOGY · PI ANASTASIO, MARK A, WANG, LIHONG · 2017 to 2021
$3.0M
FAST HIGH-RESOLUTION DEEP PHOTOACOUSTIC TOMOGRAPHY OF ACTION POTENTIALS IN BRAINSU01NS090579 · NINDS · WASHINGTON UNIVERSITY · PI WANG, LIHONG · 2014 to 2016
$2.7M
NIBIB NIH HHS DP1 EB016986NINDS NIH HHS R01 NS102213NINDS NIH HHS U01 NS090579NINDS NIH HHS U01 NS099717
6 · The paper itself

Abstract

An ultra-long light needle is highly desired in optical microscopy for its ability to improve the lateral resolution over a large depth of field (DOF). However, its use in image acquisition usually relies on mechanical raster scanning, which compromises between imaging speed and stability and thereby restricts imaging performance. Here, we propose a synthetic Bessel light needle (SBLN) that can be generated and scanned digitally by complex field modulation using a digital micromirror device. In particular, the SBLN achieves a 45-fold improvement in DOF over its counterpart Gaussian focus. Further, we apply the SBLN to perform motionless two-dimensional and three-dimensional microscopic imaging, achieving both improved resolution and extended DOF. Our work is expected to open up opportunities for potential biomedical applications.

Identifiers

PMID30449893
PMCPMC6214810

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.