Evidence map›Paper›PMID 30449784›Full record

ArticleInternal medicine (Tokyo, Japan)2019

Successful Bridging Chemotherapy with Gemcitabine, Carboplatin, and Dexamethasone before Unrelated Stem Cell Transplantation for Hepatosplenic T-cell Lymphoma.

Marika Okuni, Kimikazu Yakushijin, Keiichiro Uehara, Hiroya Ichikawa, Hirotaka Suto, Akiko Hashimoto, Yasuhiro Tanaka, Isaku Shinzato, Rina Sakai, Yu Mizutani and 11 more

Open access · diamondAbstract readCase Reports
In one paragraph

Article in Internal medicine (Tokyo, Japan), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.8field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 5 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors at 3 institutions in 1 country.

Marika OkuniThe Division of Medical Oncology and Hematology, Department of Medicine, Kobe University Hospital, Japan.
Kimikazu YakushijinThe Division of Medical Oncology and Hematology, Department of Medicine, Kobe University Hospital, Japan.
Keiichiro UeharaDepartment of Diagnostic Pathology, Kobe University Hospital, Japan.
Hiroya IchikawaThe Division of Medical Oncology and Hematology, Department of Medicine, Kobe University Hospital, Japan.
Hirotaka SutoThe Division of Medical Oncology and Hematology, Department of Medicine, Kobe University Hospital, Japan.
Akiko HashimotoDepartment of Hematology and Clinical Immunology, Kobe City Nishi-Kobe Medical Center, Japan.
Yasuhiro TanakaDepartment of Hematology and Clinical Immunology, Kobe City Nishi-Kobe Medical Center, Japan.
Isaku ShinzatoDepartment of Hematology and Clinical Immunology, Kobe City Nishi-Kobe Medical Center, Japan.
Rina SakaiThe Division of Medical Oncology and Hematology, Department of Medicine, Kobe University Hospital, Japan.
Yu MizutaniThe Division of Medical Oncology and Hematology, Department of Medicine, Kobe University Hospital, Japan.
Shigeki NagaoThe Division of Medical Oncology and Hematology, Department of Medicine, Kobe University Hospital, Japan.
Keiji KurataThe Division of Medical Oncology and Hematology, Department of Medicine, Kobe University Hospital, Japan.
Seiji KakiuchiThe Division of Medical Oncology and Hematology, Department of Medicine, Kobe University Hospital, Japan.
Yoshiharu MiyataThe Division of Medical Oncology and Hematology, Department of Medicine, Kobe University Hospital, Japan.
Yumiko InuiThe Division of Medical Oncology and Hematology, Department of Medicine, Kobe University Hospital, Japan.
Yasuyuki SaitoDivision of Molecular and Cellular Signaling, Department of Biochemistry and Molecular Biology, Kobe University Graduate School of Medicine, Japan.
Shinichiro KawamotoThe Division of Medical Oncology and Hematology, Department of Medicine, Kobe University Hospital, Japan.
Katsuya YamamotoThe Division of Medical Oncology and Hematology, Department of Medicine, Kobe University Hospital, Japan.
Mitsuhiro ItoLaboratory of Hematology, Division of Medical Biophysics, Kobe University Graduate School of Health Sciences, Japan.
Hiroshi MatsuokaThe Division of Medical Oncology and Hematology, Department of Medicine, Kobe University Hospital, Japan.
Hironobu MinamiThe Division of Medical Oncology and Hematology, Department of Medicine, Kobe University Hospital, Japan.
Kobe University Hospital · JPKobe City Nishi-Kobe Medical Center · JPKobe University · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A 45-year-old woman was diagnosed with hepatosplenic T-cell lymphoma (HSTCL), a rare subtype of peripheral T-cell lymphoma. She received different types of chemotherapy, but disease progression was observed. To reduce the tumor burden before an unrelated bone marrow transplantation, combination chemotherapy consisting of the gemcitabine, carboplatin, and dexamethasone (GCD) was administered as bridging therapy, resulting in a reduction in the number of lymphoma cells. We were then able to perform bone marrow transplantation. Although she experienced some adverse events, she successfully achieved long-term remission. We herein report a successful case of HSTCL treated with unrelated stem cell transplantation following the GCD regimen as bridging chemotherapy.

Indexed as

Antineoplastic Combined Chemotherapy ProtocolsCarboplatinCombined Modality TherapyDeoxycytidineDexamethasoneFemaleGemcitabineHematopoietic Stem Cell TransplantationHumansLiver NeoplasmsLymphoma, T-Cell, PeripheralMiddle AgedSplenic NeoplasmsCarboplatinDeoxycytidineDexamethasoneGemcitabineallogeneic stem cell transplantationbridging therapyGCDhepatosplenic T-cell lymphoma

Identifiers

PMID30449784
PMCPMC6443557
OpenAlexW2900992548

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.