Evidence map›Paper›PMID 30449703›Full record

ArticleStem cell reports2018

Genome Toxicity and Impaired Stem Cell Function after Conditional Activation of CreER

Natacha Bohin, Elizabeth A Carlson, Linda C Samuelson

Open access · goldAbstract read
In one paragraph

Article in Stem cell reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed
2.2field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed, 44 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Intestinal Epithelial Regeneration in Response to Ionizing Irradiation.Journal of visualized experiments : JoVE · 2022
    Article
  11. Inducible SystemicInternational journal of molecular sciences · 2022
    Article
  12. Survival of Stem Cells and Progenitors in the Intestine Is Regulated by LPACellular and molecular gastroenterology and hepatology · 2022
    Article
  13. Article
  14. Article
  15. Article
  16. Review
  17. Article
  18. Article
  19. Review
  20. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Natacha BohinDepartment of Molecular & Integrative Physiology, University of Michigan, Ann Arbor, MI 48109, USA; Cellular & Molecular Biology Graduate Program, University of Michigan, Ann Arbor, MI 48109, USA.
Elizabeth A CarlsonDepartment of Molecular & Integrative Physiology, University of Michigan, Ann Arbor, MI 48109, USA.
Linda C SamuelsonDepartment of Molecular & Integrative Physiology, University of Michigan, Ann Arbor, MI 48109, USA; Cellular & Molecular Biology Graduate Program, University of Michigan, Ann Arbor, MI 48109, USA. Electronic address: lcsam@umich.edu.
University of Michigan–Ann Arbor · US

Funding

University of Michigan Center for Gastrointestinal ResearchP30DK034933 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI OWYANG, CHUNG · 1986 to 2021
$22.5M
Mechanisms of Intestinal Stem Cell Injury and RepairR01DK118023 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI SAMUELSON, LINDA C. · 2018 to 2021
$1.7M
Notch Pathway Regulation of Intestinal Epithelial Cell HomeostasisR01DK096972 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI SAMUELSON, LINDA C. · 2013 to 2016
$1.3M
NIDDK NIH HHS P30 DK034933NIDDK NIH HHS R01 DK096972NIDDK NIH HHS R01 DK118023
6 · The paper itself

Abstract

With the tamoxifen-inducible CreER

Indexed as

GenomeAnimalsDNA CleavageIntegrasesIntestinesMice, Inbred C57BLMicrofilament ProteinsOrganoidsReceptors, EstrogenRegenerationStem CellsTamoxifenCre recombinaseIntegrasesMicrofilament ProteinsReceptors, EstrogenTamoxifenvillinCreERT2crypt regenerationgenotoxicityintestinal stem cellloxPmouseorganoidtamoxifen

Identifiers

PMID30449703
PMCPMC6294112
OpenAlexW2901273531

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.