Trial reportEuropean journal of paediatric neurology : EJPN : official journal of the European Paediatric Neurology Society2019
Two-minute versus 6-minute walk distances during 6-minute walk test in neuromuscular disease: Is the 2-minute walk test an effective alternative to a 6-minute walk test?
Trial report in European journal of paediatric neurology : EJPN : official journal of the European Paediatric Neurology Society, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed, 1 synthesis or guideline pooled it, 39 citations in OpenAlex.
- Walking test outcomes in adults with genetic neuromuscular diseases: a systematic literature review of their measurement properties.European journal of physical and rehabilitation medicine · 2024Pooled it
- Assessment of functional capacity in children with chronic kidney disease using various field tests.Pediatric nephrology (Berlin, Germany) · 2026Observational
- Hip exoskeleton assistance with machine-learning-based state estimation improves gait kinematics of people with Parkinson's disease.Frontiers in robotics and AI · 2026Article
- Hybrid assistive limb treatment for patients with severe cervical and thoracic myelopathy due to ossification of the posterior longitudinal ligament and ligamentum flavum: Feasibility, safety, and efficacy in the acute and chronic phases.The journal of spinal cord medicine · 2026Article
- The ILLUMINATE natural history study in colony-stimulating factor 1 receptor-related adult-onset leukoencephalopathy with axonal spheroids and pigmented glia.Brain communications · 2026Article
- Comparing the Informative Value of 2-Minute Segments of the 6-Minute Walk Test: Insights into a Prospective Study on Parkinson's Disease.Sensors (Basel, Switzerland) · 2025Article
- A model to predict the 6-Minute Walk Distance in Pompe disease.Journal of neuromuscular diseases · 2025Article
- Procedural Variation May Contribute to 6-Minute Walk Distance Variability in Real-World Pediatric Pulmonary Arterial Hypertension Study.The AAPS journal · 2025Observational
- Enhancing the effects of nusinersen with cybernic treatment using Hybrid Assistive Limb (HAL) in spinal muscular atrophy: a real-world case series and exploratory cohort analysis.Orphanet journal of rare diseases · 2025Observational
- The Effectiveness of Leg- and Arm-Powered Trike Training Among Children with Impaired Walking Ability-A Pilot Study.Children (Basel, Switzerland) · 2025Article
- Longitudinal Course of Myotonic Dystrophy Type 1 With Gait Training Using a Hybrid Assistive Limb: A Case Report.Cureus · 2024Article
- Developing normative values and predictive models for the 6-minute walk test across diverse adolescent developmental stages.European journal of sport science · 2024Article
- Phase 1 Open-Label Study of Omigapil in Patients With LAMA2- or COL6-Related Dystrophy.Neurology. Genetics · 2024Article
- Efficacy and safety of pegzilarginase in arginase 1 deficiency (PEACE): a phase 3, randomized, double-blind, placebo-controlled, multi-centre trial.EClinicalMedicine · 2024Article
- Beyond the Clinic: Maximum Free-Living Stepping as a Potential Measure of Physical Performance.Sensors (Basel, Switzerland) · 2023Article
- Effect of Treadmill Backward Walking Training on Motor Capacity in Cerebral Palsy: A Randomized Controlled Study.Annals of rehabilitation medicine · 2023Article
- Activity-Based Restorative Therapy Promotes Progression from Asymmetry to Symmetry in Posture and Gait in a Child with Chronic, Incomplete Spinal Cord Injury.Children (Basel, Switzerland) · 2023Article
- Multidimensional Biomechanics-Based Score to Assess Disease Progression in Duchenne Muscular Dystrophy.Sensors (Basel, Switzerland) · 2023Article
- Long-term progression of clinician-reported and gait performance outcomes in hereditary spastic paraplegias.Frontiers in neuroscience · 2023Article
- Validation of Body-Worn Sensors for Gait Analysis During a 2-min Walk Test in Children.Journal for the measurement of physical behaviour · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 3 institutions in 1 country.
Funding
Abstract
Functional tests such as Motor Function Measure-32 (MFM-32), supine to stand, ascend/descend stairs permit the assessment of task-specific motor function in neuromuscular disease (NMD). The 6-min walk test (6MWT), though functional, is primarily used to assess endurance and disease progression in children with neuromuscular disorders. Barriers to 6MWT administration, in this population, can include reduced attention span due to age and inability to tolerate test length due to weakness. We propose task-specific functional deficits are related to endurance. Additionally, the 2-min walk test (2MWT) could effectively replace the 6MWT in this population. Seventy-seven participants, ages 5-18, with a variety of neuromuscular disorders performed the 6MWT, timed functional tests (TFT), and the MFM-32. Correlation and paired t-test analyses were used to compare the distance walked in the first 2 min (2MWD) to the distance walked in the entire 6 min (6MWD) and to the functional outcome measures above. The 2MWD strongly correlated with 6MWD and the other outcome measures. Paired t-test analysis also showed that the 2MWD did not differ from the distance walked in the last 2 min of the 6MWT. Although equivalence testing could not reject the claim that this difference exceeded the upper practical limit of 9.5 m, it only showed a modest overestimation of the 4-6MWD compared with the 2MWD. Together, our results support the ability of the 2MWD to predict the 6MWD, specifically in the pediatric neuromuscular disease population.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.