ArticleTheoretical biology & medical modelling2018
Mathematical model of the life cycle of taenia-cysticercosis: transmission dynamics and chemotherapy (Part 1).
Article in Theoretical biology & medical modelling, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.
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Who cites it
8 citing papers in PubMed, 1 synthesis or guideline pooled it, 19 citations in OpenAlex.
- Elucidating the causal mechanisms of Taenia solium transmission in humans, pigs and the environment: A global systematic review.PLoS neglected tropical diseases · 2026Pooled it
- Mathematical modelling of the effects of public health educational campaigns on the transmission dynamics ofParasite epidemiology and control · 2026Article
- The epidemiology and spatial distribution of Taenia solium taeniosis and cysticercosis in Kenya: The case of Busia County.PLoS neglected tropical diseases · 2025Article
- Optimal control analysis ofParasite epidemiology and control · 2022Article
- Socio-economic and health costs of porcine/human cysticercosis, neurocysticercosis and epilepsy to small-scale pig producers in Tanzania.Bulletin of the National Research Centre · 2021Review
- Modelling forBulletin of the World Health Organization · 2020Article
- How to eliminate taeniasis/cysticercosis: porcine vaccination and human chemotherapy (Part 2).Theoretical biology & medical modelling · 2019Article
- The World Health Organization 2030 goals forGates open research · 2019Article
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4 authors at 1 institution in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
backgroundTaenia solium is the aetiological agent of human taeniasis, pig cysticercosis and human neurocysticercosis, which are serious public health problems, especially in developing countries.
methodsA mathematical model of the transmission dynamics of taeniasis-cysticercosis is formulated. The model consists of a coupled system of differential equations, which are density-dependent equations for describing the flow of the parasite through the life cycle. The model is hybrid since it comprises deterministic equations with stochastic elements which describe changes in the mean parasite burden and incorporates the overall pattern of the parasites' distribution.
resultsSensitivity and bifurcation analyses were carried out to determine the range of values of the model. The model can reproduce the observed epidemiological patterns of human taeniasis, pig and human cysticercosis. For example, for a wide range of parameter values, the mean intensity of adult worms tends to rapidly stabilize in one parasite per individual host. From this model, we also derived a Susceptible-Infected model to describe the prevalence of infection in humans and pigs. Chemotherapeutic interventions against pig cysticercosis or human taeniasis may reduce rapidly and effectively the mean intensity of human taeniasis, pig cysticercosis and human cysticercosis. This effect can be achieved even if the protective efficacy of the drug is of the order of 90% and the coverage rate is 90%. This means that health in humans infected either with adult worms or cysticerci may be achieved by the application of anthelmintic drugs against pig cysticercosis. However, treatment against human cysticercosis alone, does not influence neither human teniasis nor pig cysticercosis. This is because human cysticercosis infection does not influence the value of the basic reproductive number (Ro).
conclusionsEven coverage of 100% in the administration of anthelmintics did not eliminate the infection. Then elimination of the infection in all hosts does not seem a feasible goal to achieve by administering only chemotherapeutic interventions. Throughout the manuscript a discussion of our model in the context of other models of taeniasis-cysticercosis is presented.
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