Evidence map›Paper›PMID 30449238›Full record

ArticleSmall GTPases2021

Effects of RhoA and RhoC upon the sensitivity of prostate cancer cells to glutamine deprivation.

Luciana Bueno De Paiva, Vanessa Aline Bernusso, João Agostinho Machado-Neto, Fabiola Traina, Anne J Ridley, Sara Teresinha Olalla-Saad, Mariana Lazarini

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Small GTPases, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.1field-weighted citation impact, top 56% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Targeting Glutamine Metabolism in Prostate Cancer.Frontiers in bioscience (Elite edition) · 2023
    Review
  5. Article
  6. Role of RhoC in cancer cell migration.Cancer cell international · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 2 countries.

Luciana Bueno De PaivaHematology and Bloood Transfusion Center, University of Campinas , Campinas, São Paulo, Brazil.ORCID 0000-0001-5886-0490
Vanessa Aline BernussoHematology and Bloood Transfusion Center, University of Campinas , Campinas, São Paulo, Brazil.ORCID 0000-0002-6082-156X
João Agostinho Machado-NetoDepartment of Internal Medicine, University of São Paulo at Ribeirão Preto Medical School , Ribeirão Preto, São Paulo, Brazil.ORCID 0000-0002-2937-8109
Fabiola TrainaDepartment of Internal Medicine, University of São Paulo at Ribeirão Preto Medical School , Ribeirão Preto, São Paulo, Brazil.ORCID 0000-0003-4258-289X
Anne J RidleyRandall Centre of Cell & Molecular Biophysics, King´s College London , London, UK.ORCID 0000-0001-8186-5708
Sara Teresinha Olalla-SaadHematology and Bloood Transfusion Center, University of Campinas , Campinas, São Paulo, Brazil.ORCID 0000-0003-0809-8068
Mariana LazariniHematology and Bloood Transfusion Center, University of Campinas , Campinas, São Paulo, Brazil.ORCID 0000-0002-5030-7583
Universidade Estadual de Campinas (UNICAMP) · BRUniversidade de São Paulo · BRKing's College London · GB

Funding

Cancer Research UK 15961
6 · The paper itself

Abstract

RhoA and RhoC contribute to the regulation of glutamine metabolism, which is a crucial determinant of cell growth in some types of cancer. Here we investigated the participation of RhoA and RhoC in the response of prostate cancer cells to glutamine deprivation. We found that RhoA and RhoC activities were up- or downregulated by glutamine reduction in PC3 and LNCaP cell lines, which was concomitant to a reduction in cell number and proliferation. Stable overexpression of wild type RhoA or RhoC did not alter the sensitivity to glutamine deprivation. However, PC3 cells expressing dominant negative RhoA

Indexed as

GlutamineProstatic NeoplasmsrhoA GTP-Binding ProteinrhoC GTP-Binding ProteinCell Line, TumorCell ProliferationHumansMaleGlutaminerhoA GTP-Binding ProteinRHOA protein, humanrhoC GTP-Binding ProteinRHOC protein, humanglutamineLNCaP cellsPC3 cellsprostate cancerRhoARhoCRho GTPases

Identifiers

PMID30449238
PMCPMC7781845
OpenAlexW2901782539

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.