Observational studyCephalalgia : an international journal of headache2019
Altered speech with migraine attacks: A prospective, longitudinal study of episodic migraine without aura.
Observational study in Cephalalgia : an international journal of headache, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Premonitory symptoms in migraine: a systematic review and meta-analysis of observational studies reporting prevalence or relative frequency.The journal of headache and pain · 2022Pooled it
- Acoustic voice analysis of women with migraine.Arquivos de neuro-psiquiatria · 2026Article
- The impact of headache intensity on speech in participants with migraine and acute post-traumatic headache.Headache · 2025Observational
- Characterizing Prodrome (Premonitory Phase) in Migraine: Results From the PRODROME Trial Screening Period.Neurology. Clinical practice · 2025Article
- A voice-based algorithm can predict type 2 diabetes status in USA adults: Findings from the Colive Voice study.PLOS digital health · 2024Article
- Revisiting Migraine: The Evolving Pathophysiology and the Expanding Management Armamentarium.Cureus · 2023Review
- Evaluating migraine with typical aura with neuroimaging.Frontiers in human neuroscience · 2023Review
- The premonitory phase of migraine is due to hypothalamic dysfunction: revisiting the evidence.The journal of headache and pain · 2022Review
- The value of brain MRI functional connectivity data in a machine learning classifier for distinguishing migraine from persistent post-traumatic headache.Frontiers in pain research (Lausanne, Switzerland) · 2022Article
- Cerebro-Cerebellar Networks in Migraine Symptoms and Headache.Frontiers in pain research (Lausanne, Switzerland) · 2022Review
- The not so hidden impact of interictal burden in migraine: A narrative review.Frontiers in neurology · 2022Review
- Characteristics of N400 component elicited in patients who have migraine with aura.The journal of headache and pain · 2021Article
- Altered speech patterns in subjects with post-traumatic headache due to mild traumatic brain injury.The journal of headache and pain · 2021Article
- Neuroimaging clues of migraine aura.The journal of headache and pain · 2019Review
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
BACKGROUND AND
objectiveSome individuals with migraine report the presence of speech changes during their migraine attacks. The goal of this study was to compare objective features of speech during the migraine pre-attack, the migraine attack, and during the interictal period.
methodsThis was a prospective, longitudinal, observational study of adults with episodic migraine and healthy non-migraine controls. Participants provided speech samples three times per day using a speech elicitation tool included within a mobile app. Six complementary speech features that capture articulation and prosody were extracted from speech samples. Participants with migraine maintained a daily headache diary using the same app. A mixed effects model and t-tests were used to investigate differences in speech features between controls, the migraine pre-attack phase, the migraine attack, and the interictal period.
resultsIn total, 56,767 speech samples were collected, including 43,102 from 15 individuals with migraine and 13,665 from matched healthy controls. Significant group-level differences in speech features were identified between those with migraine and healthy controls and within the migraine group during the pre-attack vs. attack vs. interictal periods (all p < .05). Most consistently, speech changes occurred in the speaking rate, articulation rate and precision, and phonatory duration. Within-subject analysis revealed that seven of 15 individuals with migraine showed significant change in at least one speech feature when comparing the migraine attack vs. interictal phase and four showed similar changes when comparing the pre-attack vs. interictal phases.
conclusionsChanges in speech occurred in almost half of the individuals during migraine attacks. Once confirmed in subsequent studies, speech changes could be considered a feature of the migraine attack.
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