ArticleParasite immunology2019
High macrophage activities are associated with advanced periductal fibrosis in chronic Opisthorchis viverrini infection.
Article in Parasite immunology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
6 citing papers in PubMed, 11 citations in OpenAlex.
- Unraveling the relationship among inflammatory responses, oxidative damage, and host susceptibility toVeterinary world · 2023Article
- Inflammatory cell responses in biliary mucosa duringOpen veterinary journal · 2023Article
- Jagged-1/Notch Pathway and Key Transient Markers Involved in Biliary Fibrosis duringTropical medicine and infectious disease · 2022Article
- N-acetyl cysteine ameliorates aortic fibrosis by promoting M2 macrophage polarization in aging mice.Redox report : communications in free radical research · 2021Article
- Hepatobiliary morbidities detected by ultrasonography in Opisthorchis viverrini-infected patients before and after praziquantel treatment: a five-year follow up study.Acta tropica · 2021Article
- Gene expression in human liver fibrosis associated with Echinococcus granulosus sensu lato.Parasitology research · 2020Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
Abstract
Liver fluke infection caused by Opisthorchis viverrini induces several hepatobiliary conditions including advanced periductal fibrosis (APF) and cholangiocarcinoma (CCA), but >25% of the infected population develops APF and 1% develop CCA. The innate immune response is the first line of defence, and macrophages are critical regulators of fibrosis. We hypothesized that macrophages from infected individuals have different capacities to either promote or suppress periductal fibrosis. We compared phagocytic activities of macrophages of healthy individuals and O viverrini-infected individuals ± APF, and found that macrophages from infected individuals with APF ingested significantly higher numbers of beads compared with healthy controls and O viverrini-infected individuals without APF. To further investigate proteolytic activity, we monitored real-time phagosomal proteolysis of beads conjugated to DQ-BODIPY-BSA using live cell imaging. We show that macrophages from O viverrini-infected individuals with APF also have elevated phagosomal proteolysis activity, which is consistent with their increased phagocytic activity. Additionally, stimulated ROS production by blood monocytes was higher in individuals with APF compared with healthy controls and infected individuals without APF. These results suggest that during O viverrini infection, macrophages with high phagocytic and proteolytic activities together with elevated ROS production are the phenotypes that can promote tissue damage, which results in periductal fibrosis.
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Registered trials
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