Evidence map›Paper›PMID 30449006›Full record

ArticleAmino acids2019

Carnosine protects cardiac myocytes against lipid peroxidation products.

Jingjing Zhao, Dheeraj Kumar Posa, Vijay Kumar, David Hoetker, Amit Kumar, Smirthy Ganesan, Daniel W Riggs, Aruni Bhatnagar, Michael F Wempe, Shahid P Baba

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Amino acids, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers.

0numbers the graph read from it
0cells of the map it votes in
42citing papers in PubMed
4.4field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

42 citing papers in PubMed, 78 citations in OpenAlex.

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  13. Effect ofAquaculture nutrition · 2024
    Article
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  19. Article
  20. Physiological Roles of Carnosine in Myocardial Function and Health.Advances in nutrition (Bethesda, Md.) · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Jingjing ZhaoDepartment of Medicine, Diabetes and Obesity Center, University of Louisville, 580 South Preston Street, Delia Baxter Building, Room 421A, Louisville, KY, 40202, USA.
Dheeraj Kumar PosaDepartment of Medicine, Diabetes and Obesity Center, University of Louisville, 580 South Preston Street, Delia Baxter Building, Room 421A, Louisville, KY, 40202, USA.
Vijay KumarSkaggs School of Pharmacy and Pharmaceutical Sciences, University of Colorado, Aurora, CO, USA.
David HoetkerDepartment of Medicine, Diabetes and Obesity Center, University of Louisville, 580 South Preston Street, Delia Baxter Building, Room 421A, Louisville, KY, 40202, USA.
Amit KumarSkaggs School of Pharmacy and Pharmaceutical Sciences, University of Colorado, Aurora, CO, USA.
Smirthy GanesanDepartment of Medicine, Diabetes and Obesity Center, University of Louisville, 580 South Preston Street, Delia Baxter Building, Room 421A, Louisville, KY, 40202, USA.
Daniel W RiggsDepartment of Medicine, Diabetes and Obesity Center, University of Louisville, 580 South Preston Street, Delia Baxter Building, Room 421A, Louisville, KY, 40202, USA.
Aruni BhatnagarDepartment of Medicine, Diabetes and Obesity Center, University of Louisville, 580 South Preston Street, Delia Baxter Building, Room 421A, Louisville, KY, 40202, USA.
Michael F WempeSkaggs School of Pharmacy and Pharmaceutical Sciences, University of Colorado, Aurora, CO, USA.
Shahid P BabaDepartment of Medicine, Diabetes and Obesity Center, University of Louisville, 580 South Preston Street, Delia Baxter Building, Room 421A, Louisville, KY, 40202, USA. spbaba01@louisville.edu.
University of Louisville · USUniversity of Colorado Anschutz Medical Campus · US

Funding

Project 5 - Metabolomic Analysis of AtherothrombosisP20GM103492 · NIGMS · UNIVERSITY OF LOUISVILLE · PI BABA, SHAHID P · 2012 to 2017
$13.8M
TOXICITY OF 4-HYDROXYALKENALS IN HEARTR01HL055477 · NHLBI · UNIVERSITY OF TEXAS MEDICAL BR GALVESTON · PI BHATNAGAR, ARUNI · 1997 to 2015
$4.4M
Cardiac pathophysiology of histidyl dipeptidesR01HL122581 · NHLBI · UNIVERSITY OF LOUISVILLE · PI BABA, SHAHID P · 2014 to 2018
$2.8M
National Institute of Health GM103492National Institute of Health R01HL122581-01 R01HL55477 GM103492National Institute of Health R01HL55477NHLBI NIH HHS R01 HL055477NHLBI NIH HHS R01 HL122581NIGMS NIH HHS P20 GM103492
6 · The paper itself

Abstract

Endogenous histidyl dipeptides such as carnosine (β-alanine-L-histidine) form conjugates with lipid peroxidation products such as 4-hydroxy-trans-2-nonenal (HNE and acrolein), chelate metals, and protect against myocardial ischemic injury. Nevertheless, it is unclear whether these peptides protect against cardiac injury by directly reacting with lipid peroxidation products. Hence, to examine whether changes in the structure of carnosine could affect its aldehyde reactivity and metal chelating ability, we synthesized methylated analogs of carnosine, balenine (β-alanine-N

Indexed as

AcroleinAnimalsCarnosineDipeptidesLipid PeroxidationMethylationMiceMice, Inbred C57BLMyocytes, CardiacProtective AgentsAcroleinCarnosineDipeptidesN(beta)-alanyl-1-methyl-histidineProtective Agents4-Hydroxy-trans-2-nonenalAcroleinCardiac myocytesHistidyl dipeptides

Identifiers

PMID30449006
PMCPMC6377314
OpenAlexW2900574893

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.