Evidence map›Paper›PMID 30448294›Full record

ArticleBiochimica et biophysica acta. General subjects2019

IL-15 improves skeletal muscle oxidative metabolism and glucose uptake in association with increased respiratory chain supercomplex formation and AMPK pathway activation.

L Nadeau, D A Patten, A Caron, L Garneau, E Pinault-Masson, M Foretz, P Haddad, B G Anderson, L S Quinn, K Jardine and 4 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biochimica et biophysica acta. General subjects, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed
2.9field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed, 49 citations in OpenAlex.

  1. Trial
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  11. Inflammation-Insulin Resistance Crosstalk and the Central Role of Myokines.International journal of molecular sciences · 2025
    Review
  12. Article
  13. Article
  14. Exerkines and myokines in aging sarcopenia.Frontiers in endocrinology · 2025
    Review
  15. Review
  16. Article
  17. Article
  18. Review
  19. Sarcopenia and COVID-19 Outcomes.Clinical interventions in aging · 2023
    Review
  20. Mechanisms by Which Skeletal Muscle Myokines Ameliorate Insulin Resistance.International journal of molecular sciences · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 7 institutions in 3 countries.

L NadeauInstitut du Savoir Montfort - Recherche, Ottawa, ON, Canada; University of Ottawa, Faculty of Medicine, Department of Biochemistry, Microbiology, and Immunology, Ottawa, ON, Canada.
D A PattenUniversity of Ottawa, Faculty of Medicine, Department of Biochemistry, Microbiology, and Immunology, Ottawa, ON, Canada.
A CaronInstitut du Savoir Montfort - Recherche, Ottawa, ON, Canada; University of Ottawa, Faculty of Medicine, Department of Biochemistry, Microbiology, and Immunology, Ottawa, ON, Canada.
L GarneauInstitut du Savoir Montfort - Recherche, Ottawa, ON, Canada; University of Ottawa, Faculty of Medicine, Department of Biochemistry, Microbiology, and Immunology, Ottawa, ON, Canada.
E Pinault-MassonInstitut du Savoir Montfort - Recherche, Ottawa, ON, Canada; University of Ottawa, Faculty of Science, Ottawa, ON, Canada.
M ForetzINSERM, U1016, Institut Cochin, Paris 75014, France; CNRS, UMR8104, Paris 75014, France; Université Paris Descartes, Sorbonne Paris Cité, Paris 75014, France.
P HaddadInstitut du Savoir Montfort - Recherche, Ottawa, ON, Canada; University of Ottawa, Faculty of Science, Ottawa, ON, Canada.
B G AndersonDivision of Gerontology and Geriatric Medicine, Department of Medicine, University of Washington, Seattle, WA, United States.
L S QuinnDivision of Gerontology and Geriatric Medicine, Department of Medicine, University of Washington, Seattle, WA, United States.
K JardineOttawa Hospital Research Institute, Ottawa, ON, Canada.
M W McBurneyOttawa Hospital Research Institute, Ottawa, ON, Canada.
E E PistilliWest Virginia University School of Medicine, Morgantown, WV, United States.
M E HarperUniversity of Ottawa, Faculty of Medicine, Department of Biochemistry, Microbiology, and Immunology, Ottawa, ON, Canada.
C AguerInstitut du Savoir Montfort - Recherche, Ottawa, ON, Canada; University of Ottawa, Faculty of Medicine, Department of Biochemistry, Microbiology, and Immunology, Ottawa, ON, Canada. Electronic address: celineaguer@montfort.on.ca.
Institut du Savoir Montfort · CAUniversity of Ottawa · CAUniversity of Washington · USInstitut Cochin · FROttawa Hospital · CAOttawa Hospital Research InstituteWest Virginia University · US

Funding

WVU Flow Cytometry and Single Cell Core Facility (FCSCCF)P20GM121322 · NIGMS · WEST VIRGINIA UNIVERSITY · PI William Harry Walker · 2018 to 2026
$22.4M
CIHR FDN143278NIGMS NIH HHS P20 GM121322
6 · The paper itself

Abstract

backgroundIL-15 is believed to play a role in the beneficial impact of exercise on muscle energy metabolism. However, previous studies have generally used supraphysiological levels of IL-15 that do not represent contraction-induced IL-15 secretion.

methodsL6 myotubes were treated acutely (3 h) and chronically (48 h) with concentrations of IL-15 mimicking circulating (1-10 pg/ml) and muscle interstitial (100 pg/ml -20 ng/ml) IL-15 levels with the aim to better understand its autocrine/paracrine role on muscle glucose uptake and mitochondrial function.

resultsAcute exposure to IL-15 levels representing muscle interstitial IL-15 increased basal glucose uptake without affecting insulin sensitivity. This was accompanied by increased mitochondrial oxidative functions in association with increased AMPK pathway and formation of complex III-containing supercomplexes. Conversely, chronic IL-15 exposure resulted in a biphasic effect on mitochondrial oxidative functions and ETC supercomplex formation was increased with low IL-15 levels but decreased with higher IL-15 concentrations. The AMPK pathway was activated only by high levels of chronic IL-15 treatment. Similar results were obtained in skeletal muscle from muscle-specific IL-15 overexpressing mice that show very high circulating IL-15 levels.

conclusionsAcute IL-15 treatment that mimics local IL-15 concentrations enhances muscle glucose uptake and mitochondrial oxidative functions. That mitochondria respond differently to different levels of IL-15 during chronic treatments indicates that IL-15 might activate two different pathways in muscle depending on IL-15 concentrations. GENERAL SIGNIFICANCE: Our results suggest that IL-15 may act in an autocrine/paracrine fashion and be, at least in part, involved in the positive effect of exercise on muscle energy metabolism.

Indexed as

AMP-Activated Protein KinasesAnimalsCell RespirationCells, CulturedDose-Response Relationship, DrugElectron TransportGlucoseInterleukin-15MiceMice, TransgenicMitochondriaMuscle, SkeletalOxidation-ReductionRatsAMP-Activated Protein KinasesGlucoseInterleukin-15Insulin sensitivityInterleukin-15Mitochondrial supercomplexesMyokineMyotubesOxidative phosphorylation

Identifiers

PMID30448294
PMCPMC6310627
OpenAlexW2901913466

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.