Evidence map›Paper›PMID 30448249›Full record

ReviewHormones and behavior2019

Glucocorticoids and resilience.

Joanna L Spencer-Segal, Huda Akil

Abstract readReview
In one paragraph

Review in Hormones and behavior, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed.

  1. When Does Stress Build Strength? Linking Stress Physiology to Resilience in the Age of Rapid Environmental Change.BioEssays : news and reviews in molecular, cellular and developmental biology · 2026
    Review
  2. Article
  3. Article
  4. Review
  5. The neurobiology of stress: Vulnerability, resilience, and major depression.Proceedings of the National Academy of Sciences of the United States of America · 2023
    Article
  6. Article
  7. Review
  8. Article
  9. Pituitary Somatotroph Adenoma-derived Exosomes: Characterization of Nonhormonal Actions.The Journal of clinical endocrinology and metabolism · 2022
    Article
  10. Revisiting the Stress Concept: Implications for Affective Disorders.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020
    Review
  11. Review
  12. Circadian regulation of depression: A role for serotonin.Frontiers in neuroendocrinology · 2019
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Joanna L Spencer-SegalDepartment of Internal Medicine, Division of Metabolism, Endocrinology, and Diabetes, University of Michigan, Ann Arbor, MI, United States of America; Molecular and Behavioral Neuroscience Institute, University of Michigan, Ann Arbor, MI, United States of America. Electronic address: sjoanna@med.umich.edu.
Huda AkilMolecular and Behavioral Neuroscience Institute, University of Michigan, Ann Arbor, MI, United States of America.

Funding

Can Affective Resilience be Enhanced? A Developmental and Epigenetic ApproachR01MH104261 · NIMH · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI AKIL, HUDA, WATSON, STANLEY J · 2014 to 2018
$2.8M
Neural and Molecular Mechanisms of Emotional Dysfunction after SepsisK08MH116267 · NIMH · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI SPENCER-SEGAL, JOANNA LOUISE · 2018 to 2022
$845k
NIMH NIH HHS K08 MH116267NIMH NIH HHS R01 MH104261
6 · The paper itself

Abstract

All organisms endure frequent challenges to homeostasis, or stressors, that require adaptation. Depending on the individual, the context, and the magnitude of stress, this active adaptation can lead to behavioral susceptibility or resilience. The latter is an under-appreciated consequence of stress, as the damaging effects of chronic stress and chronically elevated glucocorticoids have received much more attention. We suggest here that neural pathways promoting resilience are initiated at the time of stress, and that they involve glucocorticoid signaling. By focusing on the neurobiology of resilience induction and the identification of vulnerable individuals, we may be able to intervene in the future at the time of stress to promote positive adaptation.

Indexed as

Resilience, PsychologicalStress, PsychologicalAdaptation, PhysiologicalAnimalsGlucocorticoidsHomeostasisHumansNeural PathwaysGlucocorticoids

Identifiers

PMID30448249
PMCPMC7384477

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.