ArticleBiophysical journal2018
The Second Messenger c-di-GMP Adjusts Motility and Promotes Surface Aggregation of Bacteria.
Article in Biophysical journal, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 27 citations in OpenAlex.
- c-di-GMP-mediated pause behavior enablesApplied and environmental microbiology · 2026Article
- Altering chemotaxis as a strategy to enhance the foraging range of motility-restricted bacteria.Communications biology · 2026Article
- Texas 2-step: a new model for YcgR::c-di-GMP action at the flagellar motor.Journal of bacteriology · 2025Article
- Texas 2-Step: A new Model for YcgR::c-di-GMP Action at the Flagellar Motor.bioRxiv : the preprint server for biology · 2025Article
- Speed-dependent bacterial surface swimming.Applied and environmental microbiology · 2024Article
- Flagellar brake protein YcgR interacts with motor proteins MotA and FliG to regulate the flagellar rotation speed and direction.Frontiers in microbiology · 2023Article
- The Effect of the Second Messenger c-di-GMP on Bacterial Chemotaxis in Escherichia coli.Applied and environmental microbiology · 2022Article
- The enhanced expression of genes encoding diguanylate cyclases under cold stress contributes to the adhesion and biofilm formation ofFrontiers in nutrition · 2022Article
- The Multiple Regulatory Relationship Between RNA-Chaperone Hfq and the Second Messenger c-di-GMP.Frontiers in microbiology · 2021Review
- Measurement of the Internal Frictional Drag of the Bacterial Flagellar Motor by Fluctuation Analysis.Biophysical journal · 2020Article
- A Skeptic's Guide to Bacterial Mechanosensing.Journal of molecular biology · 2020Review
- Under Elevated c-di-GMP in Escherichia coli, YcgR Alters Flagellar Motor Bias and Speed Sequentially, with Additional Negative Control of the Flagellar Regulon via the Adaptor Protein RssB.Journal of bacteriology · 2019Article
- Modulation of flagellar rotation in surface-attached bacteria: A pathway for rapid surface-sensing after flagellar attachment.PLoS pathogens · 2019Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Bacteria can use the second messenger c-di-GMP to adjust their motility in response to environmental cues. The protein YcgR, upon binding of c-di-GMP, interacts with the flagellar motor to affect the motor behavior. However, the full feature of the effects of c-di-GMP::YcgR on the flagellar motor remains unclear, and its interacting partners on the motor is still controversial. Here, we characterized the effects of c-di-GMP::YcgR on the torque-speed curve of the flagellar motor, one of the most important properties of the motor, finding that it affects the motor behavior throughout the full range of load conditions from zero to high loads by shifting the motor torque-speed curve downward. We also investigated the interacting partner on the motor through dynamical fluorescent studies, finding that c-di-GMP::YcgR mainly interacts with the motor-switch complex instead of the torque-generating units (stators). To directly test the behavioral consequence of elevated c-di-GMP levels, we measured the distribution of bacteria swimming near a surface, finding that elevated c-di-GMP levels promote bacterial aggregation on surfaces. The effects of c-di-GMP on bacterial motile behavior that we characterized here are consistent with the key role that c-di-GMP plays in the transition between motile and sedentary forms of bacterial life.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.