ArticleThe Journal of thoracic and cardiovascular surgery2019
Characterization of 3-dimensional papillary muscle displacement in in vivo ovine models of ischemic/functional mitral regurgitation.
Article in The Journal of thoracic and cardiovascular surgery, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 2 of them syntheses that pooled it.
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Who cites it
16 citing papers in PubMed, 2 syntheses or guidelines pooled it, 27 citations in OpenAlex.
- Ischemic functional mitral regurgitation: from pathophysiological concepts to current treatment options. A systemic review for optimal strategy.General thoracic and cardiovascular surgery · 2021Pooled it
- Exploring the Operative Strategy for Secondary Mitral Regurgitation: A Systematic Review.BioMed research international · 2021Pooled it
- Relationship Between Position, Shape, and Deformation of Papillary Muscles and Mitral Regurgitation After Transcatheter Aortic Valve Replacement.Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions · 2026Article
- Comparing surgical techniques and results of secondary ischemic mitral regurgitation: a state-of-the-art literature review.Annals of translational medicine · 2024Review
- Best treatment option for secondary mitral regurgitation surgery: a network meta-analysis of randomized and non-randomized controlled studies.Scientific reports · 2024Article
- Simulated Effects of Acute Left Ventricular Myocardial Infarction on Mitral Regurgitation in an Ovine Model.Journal of biomechanical engineering · 2024Article
- Left Ventricular Papillary Muscle: Anatomy, Pathophysiology, and Multimodal Evaluation.Diagnostics (Basel, Switzerland) · 2024Review
- Effect of papillary muscle approximation on acute ovine functional tricuspid regurgitation.Interdisciplinary cardiovascular and thoracic surgery · 2023Article
- Utilization of Engineering Advances for Detailed Biomechanical Characterization of the Mitral-Ventricular Relationship to Optimize Repair Strategies: A Comprehensive Review.Bioengineering (Basel, Switzerland) · 2023Review
- Long-term outcomes of papillary muscle relocation anteriorly for functional mitral regurgitation.Interactive cardiovascular and thoracic surgery · 2022Article
- Mitral Valve Translocation: Optimization of Patch Geometry in an Ex Vivo Model of Secondary Mitral Regurgitation.Journal of cardiovascular translational research · 2022Article
- Secondary mitral regurgitation repair techniques and outcomes: Initial clinical experience with mitral valve translocation.JTCVS techniques · 2022Article
- Surgical mitral valve repair technique considerations based on the available evidence.Turk gogus kalp damar cerrahisi dergisi · 2022Review
- Commentary: Is papillary muscle approximation the key to durable functional mitral regurgitation repair? Only time will tell.JTCVS open · 2021Article
- The Use of Subvalvular Repair for Functional Mitral Regurgitation.Annals of thoracic and cardiovascular surgery : official journal of the Association of Thoracic and Cardiovascular Surgeons of Asia · 2021Article
- The Choice of Treatment in Ischemic Mitral Regurgitation With Reduced Left Ventricular Function.The Annals of thoracic surgery · 2019Review
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Authors and funding
7 authors at 7 institutions in 2 countries.
Funding
Abstract
objectivePapillary muscle (PM) displacement contributes to ischemic/functional mitral regurgitation (IMR/FMR). The displaced PMs pull the mitral leaflets into the left ventricle (ie, toward the apex) thus hampering leaflet coaptation. Intuitively apical leaflet tethering results from apical PM displacement. The 3-dimensional directions of PM displacement are, however, incompletely characterized.
methodsData from in vivo ovine models of IMR (6-8 weeks of posterolateral infarction, n = 12) and FMR (9-21 days of rapid left ventricular pacing, n = 11) were analyzed. All sheep had radiopaque markers implanted on the anterior and posterior PM (PPM) tips, around the mitral annulus, and on the left ventricular apex. To explore 3-dimensional PM displacement directions, differences in marker coordinates were calculated at end-systole before and during IMR/FMR using a right-handed coordinate system centered on the mitral annular "saddle horn" with the y-axis passing through the apical marker.
resultsNo apical PM displacement was observed during either IMR or FMR. The anterior PM displaced laterally during FMR. Posterolateral PPM displacement was observed during IMR and FMR.
conclusionsExperimental in vivo ovine models suggest posterolateral PPM displacement as a predominant pathomechanism leading to apical leaflet tethering during IMR/FMR.
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