ArticleEnvironmental research2019
Predictors of urinary phthalate biomarker concentrations in postmenopausal women.
Article in Environmental research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
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Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Systematic review and meta-analysis on the association between phthalates exposure and insulin resistance.Environmental science and pollution research international · 2019Pooled it
- Associations of food security and food assistance with cardiovascular morbidity and mortality among postmenopausal women from the women's health initiative.Journal of epidemiology and community health · 2026Article
- Psychiatric disorders among older U.S. women by socioeconomic and veteran status.Journal of affective disorders · 2025Article
- Associations between urinary biomarkers of phthalates and phthalate alternatives and female sexual function in a North American cohort.The journal of sexual medicine · 2025Article
- Article
- Pathways From Socioeconomic Factors to Major Cardiovascular Events Among Postmenopausal Veteran and Nonveteran Women: Findings From the Women's Health Initiative.Journal of the American Heart Association · 2024Article
- Phthalates and Incident Diabetes in Midlife Women: The Study of Women's Health Across the Nation (SWAN).The Journal of clinical endocrinology and metabolism · 2023Article
- Associations of individual and cumulative urinary phthalate and replacement biomarkers with gestational weight gain through late pregnancy.The Science of the total environment · 2023Article
- Urinary phthalate metabolite concentrations and hot flash outcomes: Longitudinal associations in the Midlife Women's Health Study.Environmental research · 2023Article
- Protective effects of polyphenols against endocrine disrupting chemicals.Food science and biotechnology · 2022Review
- Correlates of non-persistent endocrine disrupting chemical mixtures among reproductive-aged Black women in Detroit, Michigan.Chemosphere · 2022Article
- Urinary phthalate metabolites in pregnant women: occurrences, related factors, and association with maternal hormones.Environmental science and pollution research international · 2022Article
- Exposure to phthalates and cardiovascular diseases in Chinese with type 2 diabetes.Environmental science and pollution research international · 2021Article
- Urinary Phthalate Biomarkers and Bone Mineral Density in Postmenopausal Women.The Journal of clinical endocrinology and metabolism · 2021Article
- Correlates of urinary concentrations of phthalate and phthalate alternative metabolites among reproductive-aged Black women from Detroit, Michigan.Journal of exposure science & environmental epidemiology · 2021Article
- Demographic Assessment of Mono(2-ethylhexyl) Phthalate (MEHP) and Monoethyl Phthalate (MEP) Concentrations in Common Bottlenose Dolphins (GeoHealth · 2021Article
- Biomarkers of phthalates and inflammation: Findings from a subgroup of Women's Health Initiative participants.International journal of hygiene and environmental health · 2021Article
- Association of phthalate exposure and endogenous hormones with self-reported sleep disruptions: results from the Midlife Women's Health Study.Menopause (New York, N.Y.) · 2020Article
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Authors and funding
11 authors.
Funding
Abstract
backgroundPhthalates are ubiquitous endocrine disrupting chemicals present in a wide variety of consumer products. However, the personal characteristics associated with phthalate exposure are unclear.
objectivesWe sought to describe personal, behavioral, and reproductive characteristics associated with phthalate metabolite concentrations in an ongoing study nested within the Women's Health Initiative (WHI). MATERIALS AND
methodsWe measured thirteen phthalate metabolites in two or three archived urine samples collected in 1993-2001 from each of 1257 WHI participants (2991 observations). We fit multivariable generalized estimating equation models to predict urinary biomarker concentrations from personal, behavioral, and reproductive characteristics.
resultsOlder age was predictive of lower concentrations of monobenzyl phthalate (MBzP), mono-carboxyoctyl phthalate (MCOP), mono-3-carboxypropyl phthalate (MCPP), and the sum of di-n-butyl phthalate metabolites (ΣDBP). Phthalate metabolite concentrations varied by race/region, with generally higher concentrations observed among non-Whites and women from the West region. Higher neighborhood socioeconomic status predicted lower MBzP concentrations, and higher education predicted lower monoethyl phthalate (MEP) and higher concentrations of the sum of metabolites of di-isobutyl phthalate (ΣDiBP). Overweight/obesity predicted higher MBzP, MCOP, monocarboxynonyl phthalate (MCNP), MCPP, and the sum of metabolites of di(2-ethylhexyl) phthalate (ΣDEHP) and lower MEP concentrations. Alcohol consumption predicted higher concentrations of MEP and ΣDBP, while current smokers had higher ΣDBP concentrations. Better diet quality as assessed by Healthy Eating Index 2005 scores predicted lower concentrations of MBzP, ΣDiBP, and ΣDEHP.
conclusionFactors predictive of lower biomarker concentrations included increased age and healthy behaviors (e.g. lower alcohol intake, lower body mass index, not smoking, higher quality diet, and moderate physical activity). Racial group (generally higher among non-Whites) and geographic regions (generally higher in Northeast and West compared to South regions) also were predictive of phthalate biomarker concentrations.
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