Evidence map›Paper›PMID 30447281›Full record

ArticleBrain, behavior, and immunity2019

Removal of microglial-specific MyD88 signaling alters dentate gyrus doublecortin and enhances opioid addiction-like behaviors.

Phillip D Rivera, Richa Hanamsagar, Matthew J Kan, Phuong K Tran, David Stewart, Young Chan Jo, Michael Gunn, Staci D Bilbo

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Brain, behavior, and immunity, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed, 1 pooled it
2.3field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 1 synthesis or guideline pooled it, 39 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Review
  4. Article
  5. Article
  6. Article
  7. Article
  8. Substance Use and Addiction.Advances in neurobiology · 2024
    Review
  9. Article
  10. Review
  11. Review
  12. Review
  13. Distinct Cell-specific Roles of NOX2 and MyD88 in Epileptogenesis.Frontiers in cell and developmental biology · 2022
    Review
  14. Review
  15. Review
  16. Article
  17. Review
  18. The role of gut-immune-brain signaling in substance use disorders.International review of neurobiology · 2021
    Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 5 institutions in 1 country.

Phillip D RiveraProgram in Neuroscience, Harvard Medical School, Boston, MA, USA; Department of Pediatrics, Lurie Center for Autism, MassGeneral Hospital for Children, Boston, MA, USA; Department of Psychology & Neuroscience, Duke University, Durham, NC, USA; Department of Biology, Hope College, Holland, MI, USA.
Richa HanamsagarProgram in Neuroscience, Harvard Medical School, Boston, MA, USA; Department of Pediatrics, Lurie Center for Autism, MassGeneral Hospital for Children, Boston, MA, USA; Department of Psychology & Neuroscience, Duke University, Durham, NC, USA.
Matthew J KanDepartment of Immunology, Duke University Medical Center, Durham, NC, USA; Department of Medicine, Duke University Medical Center, Durham, NC, USA; Department of Pediatrics, University of California, San Francisco, CA, USA.
Phuong K TranDepartment of Pediatrics, Lurie Center for Autism, MassGeneral Hospital for Children, Boston, MA, USA; Department of Psychology & Neuroscience, Duke University, Durham, NC, USA.
David StewartDepartment of Psychology & Neuroscience, Duke University, Durham, NC, USA.
Young Chan JoProgram in Neuroscience, Harvard Medical School, Boston, MA, USA; Department of Pediatrics, Lurie Center for Autism, MassGeneral Hospital for Children, Boston, MA, USA.
Michael GunnDepartment of Immunology, Duke University Medical Center, Durham, NC, USA; Department of Medicine, Duke University Medical Center, Durham, NC, USA.
Staci D BilboProgram in Neuroscience, Harvard Medical School, Boston, MA, USA; Department of Pediatrics, Lurie Center for Autism, MassGeneral Hospital for Children, Boston, MA, USA; Department of Psychology & Neuroscience, Duke University, Durham, NC, USA. Electronic address: sbilbo@mgh.harvard.edu.
Center for Autism and Related Disorders · USDuke University · USHarvard University · USDuke Medical Center · USDuke University Hospital · US

Funding

Neural-Glial Interactions and Opioid Abuse: Modulation by Early-Life ExperienceR01DA034185 · NIDA · MASSACHUSETTS GENERAL HOSPITAL · PI BILBO, STACI D · 2013 to 2017
$1.8M
NIDA NIH HHS R01 DA034185
6 · The paper itself

Abstract

Drugs of abuse promote a potent immune response in central nervous system (CNS) via the activation of microglia and astrocytes. However, the molecular mechanisms underlying microglial activation during addiction are not well known. We developed and functionally characterized a novel transgenic mouse (Cx3cr1-CreBT

Indexed as

AnimalsBehavior, AddictiveConditioning, ClassicalConditioning, OperantDentate GyrusDoublecortin Domain ProteinsDoublecortin ProteinHippocampusMaleMemoryMiceMice, Inbred C57BLMice, TransgenicMicrogliaMicrotubule-Associated ProteinsMorphineDcx protein, mouseDoublecortin Domain ProteinsDoublecortin ProteinMicrotubule-Associated ProteinsMorphineMyd88 protein, mouseMyeloid Differentiation Factor 88NarcoticsNeuropeptidesExtinctionMicrogliaMorphineMyD88Neurogenesis

Identifiers

PMID30447281
PMCPMC6348129
OpenAlexW2901218988

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.