Evidence map›Paper›PMID 30447016›Full record

ArticleSynapse (New York, N.Y.)2019

In vivo voltammetric evidence that locus coeruleus activation predominantly releases norepinephrine in the infralimbic cortex: Effect of acute ethanol.

Alex L Deal, Maria A Mikhailova, Valentina P Grinevich, Jeff L Weiner, Raul R Gainetdinov, Evgeny A Budygin

Abstract read
In one paragraph

Article in Synapse (New York, N.Y.), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.9field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 13 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 2 countries.

Alex L DealDepartment of Neurobiology and Anatomy, Wake Forest School of Medicine, Winston-Salem, North Carolina.ORCID 0000-0003-0487-5720
Maria A MikhailovaInstitute of Translational Biomedicine, St. Petersburg State University, St. Petersburg, Russia.
Valentina P GrinevichDepartment of Neurobiology and Anatomy, Wake Forest School of Medicine, Winston-Salem, North Carolina.
Jeff L WeinerDepartment of Physiology and Pharmacology, Wake Forest School of Medicine, Winston-Salem, North Carolina.
Raul R GainetdinovInstitute of Translational Biomedicine, St. Petersburg State University, St. Petersburg, Russia.
Evgeny A BudyginDepartment of Neurobiology and Anatomy, Wake Forest School of Medicine, Winston-Salem, North Carolina.
St Petersburg University · RUWake Forest University · US

Funding

Wake Forest Translational Alcohol Research Center (WF-TARC)P50AA026117 · NIAAA · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI Jeffrey L. Weiner · 2018 to 2026
$16.2M
MULTI-DISCIPLINARY TRAINING IN THE BIOLOGY OF ALCOHOLISMT32AA007565 · NIAAA · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI BRIAN A MCCOOL · 1994 to 2026
$10.1M
Synaptic Correlates of Vulnerability and Resilience to Alcohol Use DisordersR37AA017531 · NIAAA · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI WEINER, JEFFREY L. · 2014 to 2023
$3.5M
Real-Time Accumbal Dopamine Signaling and Ethanol Drinking BehaviorR01AA022449 · NIAAA · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI BUDYGIN, EVGENY ALEXANDER · 2014 to 2018
$1.8M
NIAAA NIH HHS AA022449NIAAA NIH HHS P50 AA026117NIAAA NIH HHS P50 AA026117-01NIAAA NIH HHS R37 AA017531NIAAA NIH HHS T32AA007565
6 · The paper itself

Abstract

Using fast-scan cyclic voltammetry paired with pharmacology, the authors show that infralimbic catecholamine release following locus coeruleus stimulation is noradrenergic, but not dopaminergic, and not affected by acute ethanol. With previous work, these data suggest differential effects of ethanol on prefrontal norepinephrine and dopamine, a region important in addiction-related pathways.

Indexed as

AnimalsCentral Nervous System DepressantsEthanolEvoked PotentialsLocus CoeruleusMaleNorepinephrinePrefrontal CortexRatsRats, Long-EvansCentral Nervous System DepressantsEthanolNorepinephrinecatecholaminesethanollocus coeruleusprefrontal cortexvoltammetry

Identifiers

PMID30447016
PMCPMC12374610
OpenAlexW2901672328

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.