Evidence map›Paper›PMID 30447013›Full record

ArticleBritish journal of clinical pharmacology2019

Integrating anatomo-physiological changes and pharmacogenomics in anti-infective therapy management: is it a major concern?

Laura Beaumier, Sébastien Chanoine, Elodie Gautier-Veyret, Hélène Pluchart, Muriel Cornet, Marie-Pierre Brenier-Pinchart, Xavier Fonrose, Boubou Camara, Pierrick Bedouch

Abstract readCase Reports
In one paragraph

Article in British journal of clinical pharmacology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Laura BeaumierPôle Pharmacie, Centre Hospitalier Universitaire Grenoble Alpes, F-38000, Grenoble, France.ORCID 0000-0002-4438-0071
Sébastien ChanoinePôle Pharmacie, Centre Hospitalier Universitaire Grenoble Alpes, F-38000, Grenoble, France.
Elodie Gautier-VeyretUniversité Grenoble Alpes, F-38000, Grenoble, France.
Hélène PluchartPôle Pharmacie, Centre Hospitalier Universitaire Grenoble Alpes, F-38000, Grenoble, France.
Muriel CornetUniversité Grenoble Alpes, F-38000, Grenoble, France.
Marie-Pierre Brenier-PinchartParasitologie-Mycologie, Centre Hospitalier Universitaire Grenoble Alpes, F-38000, Grenoble, France.
Xavier FonroseLaboratoire de Pharmacologie, Pharmacogénétique et Toxicologie, Centre Hospitalier Universitaire Grenoble Alpes, F-38000, Grenoble, France.
Boubou CamaraService Hospitalier Universitaire de Pneumologie, Pôle Thorax et Vaisseaux, Centre Hospitalier Universitaire Grenoble Alpes, F-38000, Grenoble, France.
Pierrick BedouchPôle Pharmacie, Centre Hospitalier Universitaire Grenoble Alpes, F-38000, Grenoble, France.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Success of anti-infective therapy is a major challenge in some patients given anatomo-physiological changes and genetic variations. In this case anecdote, we report the management strategy of a patient suffering from chronic pulmonary aspergillosis in a context of anorexia nervosa and genetic polymorphism.

Indexed as

Administration, OralAdultAnorexia NervosaAntifungal AgentsAzolesCytochrome P-450 CYP2C19FemaleHumansIntestinal AbsorptionPharmacogenomic TestingPolymorphism, Single NucleotidePulmonary AspergillosisTreatment OutcomeAntifungal AgentsAzolesCYP2C19 protein, humanCytochrome P-450 CYP2C19cytochrome P450 enzymesdrug metabolismgenetic polymorphismpharmacogenomicstherapeutic drug monitoring

Identifiers

PMID30447013
PMCPMC6303195

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.