ArticleNeurocritical care2019
Current Practices of Intraventricular Antibiotic Therapy in the Treatment of Meningitis and Ventriculitis: Results from a Multicenter Retrospective Cohort Study.
Article in Neurocritical care, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
31 citing papers in PubMed, 61 citations in OpenAlex.
- Safety and Efficacy of Intraventricular Antibiotics for Central Nervous System Infections in Children: A Single-center Observational Study.The Pediatric infectious disease journal · 2026Observational
- Intraventricular treatment experience in children with central nervous system infections.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2026Article
- Continuous intraventricular lavage using the IRRAflow® System in refractory ventriculitis in a pediatric patient: A case report.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2026Article
- A pediatric case of severe bacterial central nervous system infection successfully treated with continuous ventriculospinal drainage.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2025Article
- Vancomycin Penetration in Brain Extracellular Fluid of Patients with Post-Surgical Central Nervous System Infections: An Exploratory Study.Medicina (Kaunas, Lithuania) · 2025Article
- Ventriculitis: A Retrospective Cohort Study of Clinical Features, Outcomes and Device Management Practices.Open forum infectious diseases · 2025Article
- Application and Safety of Externally Controlled Metronomic Drug Delivery to the Brain by an Implantable Smart Pump in a Sheep Model.Neurosurgery · 2025Article
- Short review/perspective: Critical early treatment of infections including meningitis and/or ventriculitis due to recurrent postoperative lumbar cerebrospinal fluid leaks, lumbar drains, or intracranial devices/implants.Surgical neurology international · 2025Review
- Intraventricular antibiotics for severe central nervous system infections: a case series.Scientific reports · 2024Article
- Characterizing redundancy in pharmacy residency research projects.American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists · 2024Article
- Intraventricular or intrathecal polymyxin B for treatment of post-neurosurgical intracranial infection caused by carbapenem-resistant gram-negative bacteria: a 8-year retrospective study.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2024Article
- Comprehensive Therapeutic Approaches to Tuberculous Meningitis: Pharmacokinetics, Combined Dosing, and Advanced Intrathecal Therapies.Pharmaceutics · 2024Review
- Early Intraventricular Antibiotic Therapy Improved In-Hospital-Mortality in Neurocritical Patients with Multidrug-Resistant Bacterial Nosocomial Meningitis and Ventriculitis.Neurocritical care · 2024Article
- Cefiderocol and Intraventricular Colistin for Ventriculitis due to an Extensively Drug-ResistantJournal of critical care medicine (Universitatea de Medicina si Farmacie din Targu-Mures) · 2024Article
- Stereotactic placement of dual lumen catheter system for continuous drainage, irrigation, and intraventricular antibiotic therapy for treatment of brain abscess with ventriculitis - A case report and literature review.Surgical neurology international · 2024Article
- Treatment of cerebral ventriculitis with a new self-irrigating catheter system: narrative review and case series.Journal of anesthesia, analgesia and critical care · 2023Article
- Bacterial ventriculoperitoneal shunt infections: changing trends in antimicrobial susceptibility, a 7-year retrospective study from Pakistan.Antimicrobial resistance and infection control · 2023Article
- Clinical Experience with Off-Label Intrathecal Administration of Selected Antibiotics in Adults: An Overview with Pharmacometric Considerations.Antibiotics (Basel, Switzerland) · 2023Review
- Brain abscess with pyogenic ventriculitis.IDCases · 2022Article
- Current Perspectives on the Diagnosis and Management of Healthcare-Associated Ventriculitis and Meningitis.Infection and drug resistance · 2022Review
Corrections and comments
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Authors and funding
15 authors at 14 institutions in 1 country.
Funding
Abstract
backgroundCentral nervous system (CNS) infections are particularly prevalent in the adult neurocritical care patient population and are associated with significant morbidity and mortality. Factors relevant to the nature of CNS infections pose significant challenges to clinicians treating afflicted patients. Intraventricular (IVT) administration of antibiotics may offer several benefits over systemic therapy; however, the outcomes and current practices of such treatments are poorly described in the literature.
objectiveTo describe current practices and outcomes of patients receiving intraventricular antibiotic treatment for CNS infections in neurological intensive care units of academic medical centers nationwide.
methodsA retrospective cohort study was conducted on patients admitted to intensive care units who received IVT antibiotic treatment at participating centers in the USA between January 01, 2003, and December 31, 2013. Clinical and laboratory parameters, microbiology, surgical and antimicrobial management, and treatment outcomes were collected and described.
resultsOf the 105 patients included, all received systemic antimicrobial therapy along with at least one dose of IVT antimicrobial agents. Intraventricular vancomycin was used in 52.4% of patients. The average dose was 12.2 mg/day for a median duration of 5 days. Intraventricular aminoglycosides were used in 47.5% of the patients, either alone or in combination with IVT vancomycin. The average dose of gentamicin/tobramycin was 6.7 mg/day with a median duration of 6 days. Overall mortality was 18.1%. Cerebrospinal fluid (CSF) culture sterilization occurred in 88.4% of the patients with a rate of recurrence or persistence of positive cultures of 9.5%.
conclusionIntraventricular antimicrobial agents resulted in a high CSF sterilization rate. Contemporary use of this route typically results in a treatment duration of less than a week. Prospective studies are needed to establish the optimal patient population, as well as the efficacy and safety of this route of administration.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.