SynthesisJournal of neuro-oncology2019
Effects of surgery on neurocognitive function in patients with glioma: a meta-analysis of immediate post-operative and long-term follow-up neurocognitive outcomes.
Synthesis in Journal of neuro-oncology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 50 papers, 8 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
50 citing papers in PubMed, 8 syntheses or guidelines pooled it, 82 citations in OpenAlex.
- Awake surgery versus general anesthesia in the treatment of Diffuse Low-Grade Gliomas - and the role of supplementary intraoperative techniques: a systematic review and meta-analysis.Journal of neuro-oncology · 2026Pooled it
- EANS-EANO guidelines on the extent of resection in gliomas.Neuro-oncology · 2026Guideline
- A Systematic Review of the Learning Dynamics of Proprioception Training: Specificity, Acquisition, Retention, and Transfer.Neurorehabilitation and neural repair · 2023Pooled it
- Cognitive outcomes after multimodal treatment in adult glioma patients: A meta-analysis.Neuro-oncology · 2023Pooled it
- Palliative care and end-of-life care in adults with malignant brain tumors.Neuro-oncology · 2023Pooled it
- The need to consider return to work as a main outcome in patients undergoing surgery for diffuse low-grade glioma: a systematic review.Acta neurochirurgica · 2022Pooled it
- A systematic review of the use of subcortical intraoperative electrical stimulation mapping for monitoring of executive deficits and neglect: what is the evidence so far?Acta neurochirurgica · 2022Pooled it
- Pooled it
- The BLTT (Bonn Leistungs Tracking Test) in Patients with Temporal Lobe Gliomas-Feasibility of a Novel Neurocognitive Test Battery.NeuroSci · 2026Article
- Effects of Glioblastoma Resection on Cognitive Function and Affective Symptoms at Three-Month Follow-Up.Brain and behavior · 2026Observational
- Application of multidimensional cognitive training in the early postoperative period for glioma patients with cognitive impairment.Journal of neuro-oncology · 2026Article
- Returning to work after treatment for a low-grade glioma: analysing return-to-work rates and exploring barriers experienced by patients.Journal of neuro-oncology · 2026Article
- Neurosurgery Advancements: From Technical Innovation to Patient-Centered Outcomes-A Narrative Review.Journal of clinical medicine · 2026Review
- Article
- Relationship between functional network integrity, cognition and fatigue at long-term follow-up in patients with IDH-mutated gliomas.Frontiers in human neuroscience · 2026Article
- Factors associated with cognitive impairment in long-term IDH-mutant glioma survivors.Journal of neuro-oncology · 2025Article
- Relationships of the expression levels of inflammatory factors in serum and cytokines in cerebrospinal fluid with the degree of postoperative nerve injury and prognosis in patients with Glioma.Pakistan journal of medical sciences · 2025Article
- Cognitive impact of repeated surgical resections for the management of high-grade glioma.Journal of neuro-oncology · 2025Article
- Computerized assessment of neuropsychological functioning in pediatric brain tumor patients.Journal of neuro-oncology · 2025Article
- Preoperative and intraoperative neuromonitoring and mapping techniques impact oncological and functional outcomes in supratentorial function-eloquent brain tumours: a systematic review and meta-analysis.EClinicalMedicine · 2025Article
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeThis study aims to identify the neuropsychological tests commonly used for assessment in each neurocognitive domain, and quantify the post-operative changes in neurocognitive function in the immediate post-operation and follow-up.
methodsWith the use of the PubMed, a comprehensive search of the English literature was performed following PRISMA (Preferred Reporting Items for Systematic reviews and Meta-Analyses) guidelines. There were 1021 publications identified for screening. Standardized mean differences (SMD) in neuropsychological task performance were calculated both for immediate post-operation (up to 1 week) and follow-up (up to 6 months).
resultsOut of 12 studies which met the inclusion criteria, 11 studies were analyzed in this meta-analysis, with a total of 313 patients (age range 18-82, 50% males) with intracranial gliomas (45% high-grade, 55% low-grade). Complex attention, language and executive function were the most frequently tested neurocognitive domains. Surgery had a positive impact in the domains of complex attention, language, learning and memory tasks in the immediate post-operative period and sustained improvement at follow-up. In contrast, surgery was found to negatively impact performance for executive function in the immediate post-operative period with sustained decline in performance in the long term.
conclusionsThis meta-analysis suggests that surgery for glioma confers a benefit for the domains of complex attention, language, learning and memory, while negatively affecting executive function, in the periods immediately after surgery and at 6 months follow-up. In addition, awake surgery seemed to confer a beneficial effect on neurocognitive functions. Future research should attempt to standardize a battery of neuropsychological tests for patients undergoing surgical resection for glioma, perhaps with a particular focus on executive function.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.