LAG-3: a very singular immune checkpoint.

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

Who cites it

22 citing papers in PubMed.

1. Immune receptor LAG3 regulates microglia function during Alzheimer's disease.bioRxiv : the preprint server for biology · 2026
   Article
2. Gastric cancer cells-derived exosomal miR-151a-5p induces an immunosuppressive microenvironment through promoting LAG3Journal of experimental & clinical cancer research : CR · 2026
   Article
3. LAG Time in the Era of Immunotherapy-New Molecular Insights Into the Immunosuppression Mechanism of Lymphocyte Activation Gene-3.Immunological reviews · 2025
   Review
4. Revealing the mechanisms and therapeutic potential of immune checkpoint proteins across diverse protein families.Frontiers in immunology · 2025
   Review
5. Combined Autophagy Inhibition and Dendritic Cell Recruitment Induces Antitumor Immunity and Enhances Immune Checkpoint Blockade Sensitivity in Pancreatic Cancer.Cancer research · 2024
   Article
6. Development of LAG-3/FGL1 blocking peptide and combination with radiotherapy for cancer immunotherapy.Acta pharmaceutica Sinica. B · 2024
   Article
7. The Involvement of LAG-3International journal of molecular sciences · 2023
   Article
8. Mitophagy genes in ovarian cancer: a comprehensive analysis for improved immunotherapy.Discover oncology · 2023
   Article
9. Lymphocyte activation gene 3 is increased and affects cytokine production in rheumatoid arthritis.Arthritis research & therapy · 2023
   Article
10. Expression of the immune targets in tumor-infiltrating immunocytes of gestational trophoblastic neoplasia.Pathology oncology research : POR · 2023
    Article
11. LAG3 ectodomain structure reveals functional interfaces for ligand and antibody recognition.Nature immunology · 2022
    Article
12. Retrospective analysis of the preparation and application of immunotherapy in cancer treatment (Review).International journal of oncology · 2022
    Article
13. Prognostic significance and therapeutic potentials of immune checkpoints in osteosarcoma.EXCLI journal · 2022
    Review
14. Lymphocyte Activation Gene-3 Regulates Dendritic Cell Metabolic Programing and T Cell Priming Function.Journal of immunology (Baltimore, Md. : 1950) · 2021
    Article
15. Immune profiling of pituitary tumors reveals variations in immune infiltration and checkpoint molecule expression.Pituitary · 2021
    Article
16. Checkpoint Molecules in Rheumatology-or the Benefits of Being Exhausted.Current rheumatology reports · 2021
    Review
17. What Happens to the Immune Microenvironment After PD-1 Inhibitor Therapy?Frontiers in immunology · 2021
    Review
18. Microglia promote glioblastoma via mTOR-mediated immunosuppression of the tumour microenvironment.The EMBO journal · 2020
    Article
19. Emerging Targets of Immunotherapy in Gynecologic Cancer.OncoTargets and therapy · 2020
    Review
20. A Highlight of the Mechanisms of Immune Checkpoint Blocker Resistance.Frontiers in cell and developmental biology · 2020
    Review

Corrections and comments

• Comment on
  LAG-3 inhibits the activation of CD42018

Authors and funding

2 authors.

Funding

Abstract

PubMed holds no abstract for this paper.

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