Evidence map›Paper›PMID 30446632›Full record

ArticleAging2018

ZNF185 is a p53 target gene following DNA damage.

Artem Smirnov, Angela Cappello, Anna Maria Lena, Lucia Anemona, Alessandro Mauriello, Nicola Di Daniele, Margherita Annicchiarico-Petruzzelli, Gerry Melino, Eleonora Candi

Open access · greenAbstract read
In one paragraph

Article in Aging, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
0.4field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 16 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 2 countries.

Artem SmirnovDepartment of Experimental Medicine, TOR, University of Rome "Tor Vergata", Rome 00133, Italy.
Angela CappelloDepartment of Experimental Medicine, TOR, University of Rome "Tor Vergata", Rome 00133, Italy.
Anna Maria LenaDepartment of Experimental Medicine, TOR, University of Rome "Tor Vergata", Rome 00133, Italy.
Lucia AnemonaDepartment of Experimental Medicine, TOR, University of Rome "Tor Vergata", Rome 00133, Italy.
Alessandro MaurielloDepartment of Experimental Medicine, TOR, University of Rome "Tor Vergata", Rome 00133, Italy.
Nicola Di DanieleDepartment of Systems Medicine, University of Rome "Tor Vergata", Rome 00133, Italy.
Margherita Annicchiarico-PetruzzelliIstituto Dermopatico dell'Immacolata-IRCCS, Rome 00163, Italy.
Gerry MelinoDepartment of Experimental Medicine, TOR, University of Rome "Tor Vergata", Rome 00133, Italy.
Eleonora CandiDepartment of Experimental Medicine, TOR, University of Rome "Tor Vergata", Rome 00133, Italy.
University of Rome Tor Vergata · ITIstituto Dermopatico dell'Immacolata · IT

Funding

Medical Research Council MC_U132670600Medical Research Council MC_UU_00025/2
6 · The paper itself

Abstract

The transcription factor p53 is a key player in the tumour suppressive DNA damage response and a growing number of target genes involved in these pathways has been identified. p53 has been shown to be implicated in controlling cell motility and its mutant form enhances metastasis by loss of cell directionality, but the p53 role in this context has not yet being investigated. Here, we report that ZNF185, an actin cytoskeleton-associated protein from LIM-family of Zn-finger proteins, is induced following DNA-damage. ChIP-seq analysis, chromatin crosslinking immune-precipitation experiments and luciferase assays demonstrate that

Indexed as

Biomarkers, TumorBreast NeoplasmsCarcinomaCell Line, TumorColorectal NeoplasmsCytoskeletal ProteinsDNA DamageFemaleGene Knockdown TechniquesGenomicsHumansKeratinocytesLIM Domain ProteinsRNA, MessengerTranscription FactorsTumor Suppressor Protein p53Biomarkers, TumorCytoskeletal ProteinsLIM Domain ProteinsRNA, MessengerTranscription FactorsTumor Suppressor Protein p53ZNF185 protein, humancytoskeletonDNA damageepithelial cancerp53skinZNF185

Identifiers

PMID30446632
PMCPMC6286825
OpenAlexW2900796034

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.