Evidence map›Paper›PMID 30446628›Full record

ArticleDevelopment (Cambridge, England)2018

Conserved regulation of Nodal-mediated left-right patterning in zebrafish and mouse.

Tessa G Montague, James A Gagnon, Alexander F Schier

Open access · bronzeAbstract read
In one paragraph

Article in Development (Cambridge, England), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed
2.1field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 53 citations in OpenAlex.

  1. Article
  2. Enigmatic Nodal and Lefty gene repertoire discrepancy: Latent evolutionary history revealed by vertebrate-wide phylogeny.Developmental dynamics : an official publication of the American Association of Anatomists · 2025
    Review
  3. Article
  4. The Interaction Between theInternational journal of molecular sciences · 2025
    Article
  5. Article
  6. Article
  7. Review
  8. Article
  9. Article
  10. Zebrafish Congenital Heart Disease Models: Opportunities and Challenges.International journal of molecular sciences · 2024
    Review
  11. Article
  12. Molecular mechanisms controlling the biogenesis of the TGF-β signal Vg1.Proceedings of the National Academy of Sciences of the United States of America · 2023
    Article
  13. A spatiotemporal barrier formed by Follistatin is required for left-right patterning.Proceedings of the National Academy of Sciences of the United States of America · 2023
    Article
  14. Article
  15. Article
  16. Genomic frontiers in congenital heart disease.Nature reviews. Cardiology · 2022
    Review
  17. Dand5 is involved in zebrafish tailbud cell movement.Frontiers in cell and developmental biology · 2022
    Article
  18. Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 2 countries.

Tessa G MontagueDepartment of Molecular and Cellular Biology, Harvard University, Cambridge, MA 02138, USA tessa.montague@gmail.com schier@fas.harvard.edu.ORCID 0000-0002-5918-6327
James A GagnonDepartment of Molecular and Cellular Biology, Harvard University, Cambridge, MA 02138, USA.ORCID 0000-0003-3978-6058
Alexander F SchierDepartment of Molecular and Cellular Biology, Harvard University, Cambridge, MA 02138, USA tessa.montague@gmail.com schier@fas.harvard.edu.ORCID 0000-0001-7645-5325
Harvard University · USBroad Institute · US

Funding

Genetic Mechanisms of Axis Formation in VertebratesR37GM056211 · NIGMS · HARVARD UNIVERSITY · PI SCHIER, ALEXANDER F · 2016 to 2019
$1.5M
NIGMS NIH HHS R37 GM056211
6 · The paper itself

Abstract

Nodal is the major effector of left-right axis development. In mice, Nodal forms heterodimers with Gdf1 and is inhibited by Cerl2/Dand5 at the node, and by Lefty1 in the lateral plate mesoderm (LPM). Studies in zebrafish have suggested some parallels, but also differences, between left-right patterning in mouse and zebrafish. To address these discrepancies, we generated single and double zebrafish mutants for

Indexed as

Body PatterningAnimalsGene Expression Regulation, DevelopmentalMiceModels, BiologicalMutationNodal ProteinNodal Signaling LigandsProtein MultimerizationTime FactorsZebrafishZebrafish ProteinsNodal ProteinNodal protein, mouseNodal Signaling LigandsZebrafish ProteinsCerl2Dand5Left-right patterningLeftyNodalSouthpaw

Identifiers

PMID30446628
PMCPMC6307886
OpenAlexW2901115677

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.