Evidence map›Paper›PMID 30446627›Full record

ArticleDevelopment (Cambridge, England)2018

The RhoGEF protein Plekhg5 regulates apical constriction of bottle cells during gastrulation.

Ivan K Popov, Heather J Ray, Paul Skoglund, Ray Keller, Chenbei Chang

Abstract read
In one paragraph

Article in Development (Cambridge, England), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
1.3field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 34 citations in OpenAlex.

  1. Article
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  13. Early human trophoblast development: from morphology to function.Cellular and molecular life sciences : CMLS · 2022
    Review
  14. Article
  15. Assays for Apical Constriction Using the Xenopus Model.Methods in molecular biology (Clifton, N.J.) · 2022
    Article
  16. Article
  17. Heterochromatin protein 1 beta regulates neural and neural crest development by repressing pluripotency-associated gene pou5f3.2/oct25 in Xenopus.Developmental dynamics : an official publication of the American Association of Anatomists · 2021
    Article
  18. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Ivan K PopovDepartment of Cell, Developmental, and Integrative Biology, University of Alabama at Birmingham, Birmingham, AL 35294, USA.
Heather J RayDepartment of Cell, Developmental, and Integrative Biology, University of Alabama at Birmingham, Birmingham, AL 35294, USA.
Paul SkoglundBiology Department, University of Virginia, Charlottesville, VA 22903, USA.
Ray KellerBiology Department, University of Virginia, Charlottesville, VA 22903, USA.
Chenbei ChangDepartment of Cell, Developmental, and Integrative Biology, University of Alabama at Birmingham, Birmingham, AL 35294, USA cchang@uab.edu.ORCID 0000-0001-5725-8924
University of Alabama at Birmingham · USUniversity of Virginia · US

Funding

XRAY CRYSTALLOGRAPHYP30CA013148 · NCI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI Robert S Welner · 1985 to 2026
$165.9M
Connecting signaling with cytoskeleton: Abl and Arg in vertebrate gastrulationR01GM098566 · NIGMS · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI CHANG, CHENBEI · 2012 to 2015
$1.3M
Regulation of Axial Extension in Vertebrate EmbryosR01GM099108 · NIGMS · UNIVERSITY OF VIRGINIA · PI SKOGLUND, PAUL MICHAEL · 2012 to 2015
$1.2M
NCI NIH HHS P30 CA013148NIGMS NIH HHS R01 GM098566NIGMS NIH HHS R01 GM099108
6 · The paper itself

Abstract

Apical constriction regulates epithelial morphogenesis during embryonic development, but how this process is controlled is not understood completely. Here, we identify a Rho guanine nucleotide exchange factor (GEF) gene

Indexed as

Cell PolarityGastrulationActivinsActomyosinAnimalsCytoskeletonEmbryo, NonmammalianEpithelial CellsGastrulaGene Expression Regulation, DevelopmentalGene Knockdown TechniquesGuanine Nucleotide Exchange FactorsMovementRho Guanine Nucleotide Exchange FactorsXenopus laevisXenopus ProteinsActivinsActomyosinGuanine Nucleotide Exchange FactorsPlekhg5 protein, XenopusRho Guanine Nucleotide Exchange FactorsXenopus ProteinsActinApical constrictionBottle cellGastrulationMyosinRhoGEFXenopus

Identifiers

PMID30446627
PMCPMC6307888
OpenAlexW2901169246

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.