Evidence map›Paper›PMID 30446533›Full record

ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2019

A Proposed Mechanism for Spontaneous Transitions between Interictal and Ictal Activity.

Theju Jacob, Kyle P Lillis, Zemin Wang, Waldemar Swiercz, Negah Rahmati, Kevin J Staley

Open access · bronzeAbstract read
In one paragraph

Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.4field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 23 citations in OpenAlex.

  1. Mitochondrial Glutamine Metabolism Drives Epileptogenesis in Primary Hippocampal Neurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025
    Article
  2. Article
  3. Article
  4. A Dynamic Balance between Neuronal Death and Clearance in anThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2023
    Article
  5. Ictogenesis? That's Random…..Epilepsy currents · 2022
    Article
  6. Article
  7. Unique Actions of GABA Arising from Cytoplasmic Chloride Microdomains.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021
    Article
  8. Article
  9. Article
  10. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Theju JacobMassachusetts General Hospital, Boston, Massachusetts 02114.
Kyle P LillisMassachusetts General Hospital, Boston, Massachusetts 02114.ORCID 0000-0003-0219-8113
Zemin WangBrigham and Women's Hospital, Boston, MA 02115, and.
Waldemar SwierczMassachusetts General Hospital, Boston, Massachusetts 02114.
Negah RahmatiMassachusetts General Hospital, Boston, Massachusetts 02114.ORCID 0000-0002-0709-5976
Kevin J StaleyMassachusetts General Hospital, Boston, Massachusetts 02114, Staley.Kevin@mgh.harvard.edu.ORCID 0000-0002-3072-518X
Harvard University · USBrigham and Women's Hospital · US

Funding

Biomarkers for epileptogenesis after brain injuryR01NS086364 · NINDS · MASSACHUSETTS GENERAL HOSPITAL · PI DUDEK, F. EDWARD, STALEY, KEVIN J. · 2013 to 2017
$3.2M
Mechanisms of neuronal death during epileptogenesisR37NS077908 · NINDS · MASSACHUSETTS GENERAL HOSPITAL · PI STALEY, KEVIN J. · 2015 to 2019
$2.1M
NINDS NIH HHS R01 NS086364NINDS NIH HHS R37 NS077908
6 · The paper itself

Abstract

Epileptic networks are characterized by two outputs: brief interictal spikes and rarer, more prolonged seizures. Although either output state is readily modeled

Indexed as

AlgorithmsAnimalsComputer SimulationDisease ProgressionElectroencephalographyEpilepsyExcitatory Postsynaptic PotentialsFemaleHippocampusMaleMiceMice, Inbred C57BLModels, NeurologicalNeocortexNerve NetPatch-Clamp Techniquesepilepsyictogenesismodelpropagationseizurewavefront

Identifiers

PMID30446533
PMCPMC6335741
OpenAlexW2900881044

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.