ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2019
Chemogenetic Manipulations of Ventral Tegmental Area Dopamine Neurons Reveal Multifaceted Roles in Cocaine Abuse.
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Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 63 papers.
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63citing papers in PubMed
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Who cites it
63 citing papers in PubMed, 105 citations in OpenAlex.
- Unpacking Ventral Pallidum GABA Neuron Contributions to Opioid Drug Reward in Rats.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
- Overview of the DREADDs chemogenetics and the patent landscape of their actuators.Medicinal chemistry research : an international journal for rapid communications on design and mechanisms of action of biologically active agents · 2026Review
- Interrogating roles for VTA dopamine neurons in locomotion and ultrasonic vocalizations elicited by different classes of rewarding drugs.Psychopharmacology · 2026Article
- The hindbrain-hypothalamic noradrenergic pathway controls homeostatic food intake but not cue-induced appetitive behaviors.Journal of neuroendocrinology · 2026Article
- Drug-induced changes in connectivity to midbrain dopamine cells revealed by rabies monosynaptic tracing.eLife · 2026Article
- Preclinical abuse potential testing using behavioral economics and drug self-administration demand-curve analysis: A strategy to improve resolution of drug stratification for regulatory control.Pharmacological reviews · 2026Review
- The role of the prelimbic cortex to nucleus accumbens core projection in the reinstatement of cocaine-seeking after cocaine-alcohol polysubstance use.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Article
- Cocaine induced astrocytic activation was associated with its vasoconstricting effects independent of its neuronal effects in the prefrontal cortex.Scientific reports · 2026Article
- Sex and Stress Govern the Function and Innervation of a Basolateral Amygdala to Nucleus Accumbens Corticotropin-Releasing Hormone/GABA-Expressing Projection.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
- Differential effects of acute versus repeated chemogenetic activation of the mesocorticolimbic dopamine pathway on cocaine choice in male and female TH:Cre rats.ASPET discovery · 2026Article
- Goal-directed actions and habits in head-fixed mice.Frontiers in behavioral neuroscience · 2026Article
- Nucleus accumbens DRD2 receptor agonism attenuates escape behavior.Frontiers in neuroscience · 2026Article
- Aversion-induced dopamine reductions predict drug-taking and escape behaviors.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2025Article
- Sex-dependent modulation of behavioral allocation via ventral tegmental area-nucleus accumbens shell circuitry.NeuroImmune pharmacology and therapeutics · 2025Article
- An endogenous GLP-1 circuit engages VTA GABA neurons to regulate mesolimbic dopamine neurons and attenuate cocaine seeking.Science advances · 2025Article
- Adolescent THC impacts on mPFC dopamine-mediated cognitive processes in male and female rats.Psychopharmacology · 2025Article
- Cell types and neuronal genetic architecture in the rat CSF-contacting nucleus and the role of 5-HT in this nucleus in mediating morphine addiction through the brain-CSF circuit.Frontiers in neuroscience · 2025Article
- The ventral tegmental area dopamine to basolateral amygdala projection supports acquisition of cocaine self-administration.Neuropharmacology · 2024Article
- Opioid drug seeking after early-life adversity: a role for delta opioid receptors.Addiction neuroscience · 2024Article
- Dopamine transmission at D1 and D2 receptors in the nucleus accumbens contributes to the expression of incubation of cocaine craving.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2024Article
3 more citing papers are in PubMed but not listed here.
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Authors and funding
15 authors at 4 institutions in 1 country.
Stephen V MahlerDepartment of Neurobiology and Behavior, University of California, Irvine, Irvine, California 92697, mahlers@uci.edu.ORCID 0000-0002-8698-0905
Zachary D BrodnikDepartment of Neurobiology and Anatomy, Drexel University, Philadelphia, Pennsylvania 19129, and.ORCID 0000-0002-2847-2849
Brittney M CoxDepartment of Neurobiology and Behavior, University of California, Irvine, Irvine, California 92697.ORCID 0000-0002-7118-5300
William C BuchtaDepartment of Neuroscience, Medical University of South Carolina, Charleston, South Carolina 29425-8610.
Brandon S BentzleyDepartment of Neuroscience, Medical University of South Carolina, Charleston, South Carolina 29425-8610.ORCID 0000-0001-6014-4514
Julian QuintanillaDepartment of Neurobiology and Behavior, University of California, Irvine, Irvine, California 92697.
Zackary A CopeDepartment of Neuroscience, Medical University of South Carolina, Charleston, South Carolina 29425-8610.
Edwin C LinDepartment of Neuroscience, Medical University of South Carolina, Charleston, South Carolina 29425-8610.
Matthew D RiedyDepartment of Neuroscience, Medical University of South Carolina, Charleston, South Carolina 29425-8610.
Michael D ScofieldDepartment of Neuroscience, Medical University of South Carolina, Charleston, South Carolina 29425-8610.
Justin MessingerDepartment of Neuroscience, Medical University of South Carolina, Charleston, South Carolina 29425-8610.
Christina M RuizDepartment of Neurobiology and Behavior, University of California, Irvine, Irvine, California 92697.
Arthur C RiegelDepartment of Neuroscience, Medical University of South Carolina, Charleston, South Carolina 29425-8610.ORCID 0000-0001-7758-4436
Rodrigo A EspañaDepartment of Neurobiology and Anatomy, Drexel University, Philadelphia, Pennsylvania 19129, and.
Gary Aston-JonesBrain Health Institute, Rutgers University, Piscataway, New Jersey 08854.ORCID 0000-0002-5034-3816
Medical University of South Carolina · USDrexel University · USUniversity of California, Irvine · USRutgers, The State University of New Jersey · US
Funding
Selective Restoration of KCNQ Channel Inhibition in the PFC to Inhibit Cue-InducP50DA015369 · NIDA · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI RIEGEL, ARTHUR C · 2003 to 2017
$18.6MImpact of Cannabinoid Across the Lifespan (ICAL)P50DA044118 · NIDA · UNIVERSITY OF CALIFORNIA-IRVINE · PI Stephen Vincent Mahler · 2018 to 2026
$18.2MDRUG ABUSE TRAINING PROGRAMT32DA007288 · NIDA · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI Christopher W Cowan, Rachel Penrod-Martin · 1991 to 2026
$11.8MROLE OF OREXIN IN COCAINE DEMAND AND ADDICTIONR01DA006214 · NIDA · UNIVERSITY OF PENNSYLVANIA · PI ASTON-JONES, GARY S. · 1989 to 2024
$6.0MNRSA Training CoreTL1TR001415 · NCATS · UNIVERSITY OF CALIFORNIA-IRVINE · PI CAIOZZO, VINCENT JAMES, HEAD, ELIZABETH · 2015 to 2023
$4.2MInvolvement of hypocretin-orexin in the regulation of dopamine signaling and reinforcement processes in femalesR01DA031900 · NIDA · DREXEL UNIVERSITY · PI ESPAÑA, RODRIGO A. · 2013 to 2022
$3.6MTHE ROLE OF RYANODINE RECEPTORS IN DRUG SEEKINGR01DA046476 · NIDA · UNIVERSITY OF ARIZONA · PI RIEGEL, ARTHUR C · 2018 to 2022
$1.9MRelapse to Cocaine-Seeking: Cellular Adaptations in the Ventral Tegmental AreaR01DA033342 · NIDA · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI RIEGEL, ARTHUR C · 2012 to 2017
$1.5MRole of Ventral Pallidum Projection to VTA in Reinstatement of Cocaine SeekingR00DA035251 · NIDA · UNIVERSITY OF CALIFORNIA-IRVINE · PI MAHLER, STEPHEN VINCENT · 2015 to 2017
$756kContributions of Nitrergic Interneurons and NO Signaling in Cocaine RelapseR00DA040004 · NIDA · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI SCOFIELD, MICHAEL DAVID · 2017 to 2019
$747kRole of Ventral Pallidum Projection to VTA in Reinstatement of Cocaine SeekingK99DA035251 · NIDA · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI MAHLER, STEPHEN VINCENT · 2013 to 2014
$240kRestoration of Intrinsic Inhibition in the PFC to Prevent Relapse to Cocaine SeekF31DA036989 · NIDA · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI BUCHTA, WILLIAM CHRISTOPHER · 2014 to 2016
$112kNCATS NIH HHS TL1 TR001415NIDA NIH HHS F31 DA036989NIDA NIH HHS F31 DA042505NIDA NIH HHS K99 DA035251NIDA NIH HHS P50 DA015369NIDA NIH HHS P50 DA044118NIDA NIH HHS R00 DA035251NIDA NIH HHS R00 DA040004NIDA NIH HHS R01 DA006214NIDA NIH HHS R01 DA031900NIDA NIH HHS R01 DA033342NIDA NIH HHS R01 DA046476NIDA NIH HHS T32 DA007288
Abstract
Ventral tegmental area (VTA) dopamine (DA) neurons perform diverse functions in motivation and cognition, but their precise roles in addiction-related behaviors are still debated. Here, we targeted VTA DA neurons for bidirectional chemogenetic modulation during specific tests of cocaine reinforcement, demand, and relapse-related behaviors in male rats, querying the roles of DA neuron inhibitory and excitatory G-protein signaling in these processes. Designer receptor stimulation of G
Indexed as
AnimalsBehavior, AnimalCocaine-Related DisordersDopaminergic NeuronsDrug-Seeking BehaviorGTP-Binding ProteinsLimbic SystemMaleMotor ActivityProsencephalonRatsRats, TransgenicRecurrenceRewardSelf AdministrationSignal TransductionGTP-Binding Proteinsaddictionconditioned cuesDREADDsmotivationneural circuitsreinstatement
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.