ArticleBiological psychiatry. Cognitive neuroscience and neuroimaging2019
Restricted and Repetitive Behavior and Brain Functional Connectivity in Infants at Risk for Developing Autism Spectrum Disorder.
Article in Biological psychiatry. Cognitive neuroscience and neuroimaging, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 66 papers, 3 of them syntheses that pooled it.
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Who cites it
66 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Presymptomatic Biological, Structural, and Functional Diagnostic Biomarkers of Autism Spectrum Disorder.Journal of neurochemistry · 2025Pooled it
- Emerging behavioral and neuroimaging biomarkers for early and accurate characterization of autism spectrum disorders: a systematic review.Translational psychiatry · 2021Pooled it
- The Value of Brain Imaging and Electrophysiological Testing for Early Screening of Autism Spectrum Disorder: A Systematic Review.Frontiers in neuroscience · 2021Pooled it
- Alterations in Early Alpha-band Connectivity emerge in Infancy among children later diagnosed with Autism.medRxiv : the preprint server for health sciences · 2026Article
- Functional brain growth trajectories across the first decade of life from a single longitudinal cohort.Research square · 2026Article
- Amygdala and hippocampal contributions to broad autism phenotype: Project Ice Storm.Translational psychiatry · 2026Article
- A null findings study: graph theoretical analysis of the fetal functional connectome shows no relationships with future autistic traits.Neuroimage. Reports · 2026Article
- Fetal functional connectivity prospectively associates with autistic traits in toddlerhood.NeuroImage. Clinical · 2026Article
- Translation and Validation of the Arabic Version of the Revised Restrictive Behaviours Scale Among Iraqi Children With Autism Spectrum Disorder: A Suggestion for Model Modification.International journal of methods in psychiatric research · 2025Article
- The association between infant EEG aperiodic exponent and the trajectory of restricted and repetitive behaviors for toddlers with and without autism.Journal of neurodevelopmental disorders · 2025Article
- Task-based functional connectivity in infants after exposure to regular white noise during natural sleep measured by fNIRS.Scientific reports · 2025Article
- Associations between sleep problems, cortical morphometry, and structural brain network organization in preschool children with autism: a retrospective observational study.European journal of pediatrics · 2025Observational
- Brain functional connectivity correlates of autism diagnosis and familial liability in 24-month-olds.Journal of neurodevelopmental disorders · 2025Article
- Parental psychopathology, family conflict, brain function, and child autistic-like traits in early adolescents.Psychological medicine · 2025Article
- Rapid Eye Movements in Sleep Furnish a Unique Probe into the Ontogenetic and Phylogenetic Development of the Visual Brain: Implications for Autism Research.Brain sciences · 2025Review
- Functional connectivity between the visual and salience networks and autistic social features at school-age.Journal of neurodevelopmental disorders · 2025Article
- Statistical properties of functional connectivity MRI enrichment analysis in school-age autism research.Developmental cognitive neuroscience · 2025Article
- Age-related changes in brain signal variability in autism spectrum disorder.Molecular autism · 2025Article
- Sensory-movement underpinnings of lifelong neurodivergence: getting a grip on autism.Frontiers in integrative neuroscience · 2025Article
- Atypical Brain Connectivity During Pragmatic and Semantic Language Processing in Children with Autism.Brain sciences · 2024Article
6 more citing papers are in PubMed but not listed here.
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Authors and funding
25 authors.
Funding
Abstract
backgroundRestricted and repetitive behaviors (RRBs), detectable by 12 months in many infants in whom autism spectrum disorder (ASD) is later diagnosed, may represent some of the earliest behavioral markers of ASD. However, brain function underlying the emergence of these key behaviors remains unknown.
methodsBehavioral and resting-state functional connectivity (fc) magnetic resonance imaging data were collected from 167 children at high and low familial risk for ASD at 12 and 24 months (n = 38 at both time points). Twenty infants met criteria for ASD at 24 months. We divided RRBs into four subcategories (restricted, stereotyped, ritualistic/sameness, self-injurious) and used a data-driven approach to identify functional brain networks associated with the development of each RRB subcategory.
resultsHigher scores for ritualistic/sameness behavior were associated with less positive fc between visual and control networks at 12 and 24 months. Ritualistic/sameness and stereotyped behaviors were associated with less positive fc between visual and default mode networks at 12 months. At 24 months, stereotyped and restricted behaviors were associated with more positive fc between default mode and control networks. Additionally, at 24 months, stereotyped behavior was associated with more positive fc between dorsal attention and subcortical networks, whereas restricted behavior was associated with more positive fc between default mode and dorsal attention networks. No significant network-level associations were observed for self-injurious behavior.
conclusionsThese observations mark the earliest known description of functional brain systems underlying RRBs, reinforce the construct validity of RRB subcategories in infants, and implicate specific neural substrates for future interventions targeting RRBs.
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