Evidence map›Paper›PMID 30446209›Full record

ArticleBrazilian journal of anesthesiology (Elsevier)

[Effects of repeated exposure to different concentrations of sevoflurane on the neonatal mouse hippocampus].

Omid Azimaraghi, Maryam Nezhad Sistani, Mohammad-Amin Abdollahifar, Ali Movafegh, Anahid Maleki, Ebrahim Soltani, Alireza Shahbazkhani, Reza Atef-Yekta

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Brazilian journal of anesthesiology (Elsevier). The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.1field-weighted citation impact, top 49% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Omid AzimaraghiTehran University of Medical Sciences, Dr. Shariati Hospital, Department of Anesthesiology and Critical Care Medicine, Teerã, Irã.
Maryam Nezhad SistaniShahid Beheshti University of Medical Sciences, Department of Anatomical Sciences, Teerã, Irã.
Mohammad-Amin AbdollahifarShahid Beheshti University of Medical Sciences, Department of Anatomical Sciences, Teerã, Irã.
Ali MovafeghTehran University of Medical Sciences, Dr. Shariati Hospital, Department of Anesthesiology and Critical Care Medicine, Teerã, Irã.
Anahid MalekiTehran University of Medical Sciences, Children Medical Center Hospital, Department of Anesthesiology, Teerã, Irã.
Ebrahim SoltaniTehran University of Medical Sciences, Children Medical Center Hospital, Department of Anesthesiology, Teerã, Irã.
Alireza ShahbazkhaniTehran University of Medical Sciences, Dr. Ali Shariati Hospital, Anesthesiology Research Development Center, Teerã, Irã.
Reza Atef-YektaTehran University of Medical Sciences, Dr. Shariati Hospital, Department of Anesthesiology and Critical Care Medicine, Teerã, Irã. Electronic address: r.atefyekta@gmail.com.
Tehran University of Medical Sciences · IRShahid Beheshti University of Medical Sciences · IRShariati Hospital · IR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND AND

objectivesDeveloping brain is more vulnerable to environmental risk than is the developed brain. We evaluated the effects of repeated exposure to different concentrations of sevoflurane on the neonatal mouse hippocampus using stereological methods.

methodsEighteen neonatal male mice were randomly divided into three groups. Group A, inhaled sevoflurane at a concentration of 1.5%; Group B, inhaled sevoflurane at a concentration of 3%; and Group C (control group), inhaled only 100% oxygen. Treatments were applied for 30min a day for 7 consecutive days. The hippocampal volume, dendrite length, number of neurons, and number of glial cells were evaluated in each group using stereological estimations.

resultsWe identified a ∼2% reduction in the volume of the hippocampus in Group A compared to Group C. Mean hippocampal volume was ∼11% smaller in Group B than it was in Group C. However, these differences in hippocampal volume between the groups were not statistically significant (p>0.05 for all). As for the number of neurons, we found significantly fewer neurons in Group A (∼29% less) and Group B (∼43% less) than we did in Group C (p<0.05 for both). The dendrite length was ∼8% shorter in Group A and ∼11% shorter in Group B than it was in Group C.

conclusionsRepeated exposure to sevoflurane, regardless of the concentration, reduced the volume of the neonatal mouse hippocampus, as well as the number of neurons and dendrite length.

Indexed as

Anesthetics, InhalationAnimalsAnimals, NewbornDose-Response Relationship, DrugHippocampusMaleMiceRandom AllocationSevofluraneAnesthetics, InhalationSevofluraneEstereologiaHipocampoHippocampusNeonatal miceNeurotoxicidadeNeurotoxicityRatos neonataisSevofluraneSevofluranoStereology

Identifiers

PMID30446209
PMCPMC9391752
OpenAlexW2893317191

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.