ReviewJournal of otolaryngology - head & neck surgery = Le Journal d'oto-rhino-laryngologie et de chirurgie cervico-faciale2018
Secretory carcinoma: the eastern Canadian experience and literature review.
Review in Journal of otolaryngology - head & neck surgery = Le Journal d'oto-rhino-laryngologie et de chirurgie cervico-faciale, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.
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Who cites it
9 citing papers in PubMed, 1 synthesis or guideline pooled it, 32 citations in OpenAlex.
- Estimating survival after salvage surgery for recurrent salivary gland cancers: Systematic review.Head & neck · 2022Pooled it
- Clinicopathologic features and integrated outcome analysis of pediatric and young adult salivary secretory carcinoma.Frontiers in oncology · 2026Article
- Practical pathological methods for reliable diagnosis of secretory carcinomas of the salivary gland.Discover oncology · 2025Article
- Salivary gland secretory carcinoma presenting as a cervical soft tissue mass: a case report.Journal of medical case reports · 2024Review
- Clinicopathological features and genomic profiles of a group of secretory breast carcinomas in which progressive cases have more complex genomic features.Diagnostic pathology · 2022Article
- Mammary Analogue Secretory Carcinoma of Submandibular Gland: A Case Report with Review of the Literature.Indian journal of otolaryngology and head and neck surgery : official publication of the Association of Otolaryngologists of India · 2022Article
- Secretory carcinoma of the salivary gland, a rare entity: An international multi-institutional study.Cancer cytopathology · 2022Article
- Circulating tumor cell characterization of lung cancer brain metastases in the cerebrospinal fluid through single-cell transcriptome analysis.Clinical and translational medicine · 2020Article
- MASC Gets UNMASKED: Visiting a Rare Tumor with Emphasis on Cytomorphological Features.Journal of cytologyArticle
Corrections and comments
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Authors and funding
10 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundSecretory Carcinoma (SC) is a recently described malignancy affecting salivary glands of the head and neck, with a paucity of evidence regarding the natural history, morbidity, and mortality. This study aimed to investigate the current treatment options utilized for SC, as well as its presentation and outcomes.
methodsThis study is a retrospective case series and includes patients diagnosed with SC at four Maritime Canadian institutions. Literature review of patient outcomes following treatment of SC is also included.
resultsThirteen patients were identified. Parotid was the most common subsite (69%), followed by minor salivary gland (23%) and submandibular gland (8%). All patients were S100 positive and had at least one additional positive confirmatory stain, including mammaglobin, CK7, or vimentin. Two patients had N2b disease. All patients were treated with primary surgery, and four were offered adjuvant radiotherapy. There was one instance of locoregional recurrence, and one of metastasis. Three patients displayed perineural invasion on pathology, and one patient displayed lymphovascular invasion.
conclusionSecretory Carcinoma remains understudied regarding its natural history, presentation, and treatment options. This study is the largest single case series in Canada, and highlights the young age and possible aggressiveness of SC. As well, we provide the most comprehensive literature review to date, with a focus on treatment and outcomes for this disease entity.
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