ArticleInfectious diseases of poverty2018
Whole-genome sequencing and analysis of Plasmodium falciparum isolates from China-Myanmar border area.
Article in Infectious diseases of poverty, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed.
- Genome-Wide Analysis of the Malaria ParasiteFrontiers in immunology · 2020Trial
- Immunodominant B-cell epitopes for precision surveillance ofEmerging microbes & infections · 2026Article
- Module-level recombination drives DBLMSP polymorphism and functional conservation in Plasmodium falciparum.Parasite (Paris, France) · 2026Article
- Genomic investigation of a non-travel Plasmodium falciparum case linked to imported malaria in China's post-elimination era.Malaria journal · 2025Article
- Plasmodium vivax tryptophan-rich antigen reduces type I collagen secretion via the NF-κBp65 pathway in splenic fibroblasts.Parasites & vectors · 2024Article
- Retrospective analysis ofFrontiers in microbiology · 2023Article
- Whole Genome Sequencing Contributions and Challenges in Disease Reduction Focused on Malaria.Biology · 2022Review
- From 30 million to zero malaria cases in China: lessons learned for China-Africa collaboration in malaria elimination.Infectious diseases of poverty · 2021Article
- A Molecular Investigation of Malaria Infections From High-Transmission Areas of Southern Togo Reveals Different Species ofFrontiers in microbiology · 2021Article
- Population genomics of Vibrionaceae isolated from an endangered oasis reveals local adaptation after an environmental perturbation.BMC genomics · 2020Article
- Cholesterol-dependent enrichment of understudied erythrocytic stages of human Plasmodium parasites.Scientific reports · 2020Article
- Evaluation of antibody responses to the early transcribed membrane protein family in Plasmodium vivax.Parasites & vectors · 2019Article
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Abstract
backgroundChina has made progress in malaria control and aims to eliminate malaria nationwide, but implementing effective interventions along the border regions remain a huge task. The Plasmodium falciparum cases imported from Southeast Asia has frequently reported especially in the China-Myanmar border (CMB) area. Though, information is scant on P. falciparum genetic variability in this area.
methodsThis study reported P. falciparum isolates genome sequence of six clinical isolates in the CMB area. Furthermore, we estimated the nucleotide diversity, Watterson's estimator and Tajima's D value for the whole genome mutation rate in slide window.
resultsOur data were aligned onto 96.05-98.61% of the reference 3D7 genome in high fold coverages. Principal component analysis result showed that P. falciparum clustered generally according to their geographic origin. A total of 91 genes were identified as positive selection with Ka/Ks ratio significantly higher than 1, and most of them were multigene families encoding variant surface antigens (VSAs) such as var, rif and stevor. The enrichment of the positive selection on VSA genes implied that the environment complexity subjected CMB's P. falciparum to more pressure for survival.
conclusionsOur research suggests that greater genetic diversity in CMB area and the positive selection signals in VSA genes, which allow P. falciparum to fit the host immune system well and aggravate the difficulty of treatment. Meanwhile, results obtained from this study will provide the fundamental basis for P. falciparum population genomic research in CMB area.
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