ArticleBMC women's health2018
Follicular flushing increases the number of oocytes retrieved in poor ovarian responders undergoing in vitro fertilization: a retrospective cohort study.
Article in BMC women's health, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed, 20 citations in OpenAlex.
- Evaluation of follicular flushing with double lumen needle in patients undergoing assisted reproductive technology treatments.JBRA assisted reproduction · 2021Trial
- Follicular flushing leads to higher oocyte yield in monofollicular IVF: a randomized controlled trial.Human reproduction (Oxford, England) · 2020Trial
- ICSI shows no advantage over conventional IVF in patients with unexpected low oocyte yield.Annals of medicine · 2026Article
- The value of LH maximum level in predicting optimal oocyte yield following GnRH agonist trigger.Frontiers in endocrinology · 2023Article
- What is the optimum number of follicular flushes in mono-follicular in-vitro fertilization cycles in a poor responder population?Journal of the Turkish German Gynecological Association · 2022Article
- Low vitamin D levels in follicular fluid, but not in serum, are associated with adverse outcomes in assisted reproduction.Archives of gynecology and obstetrics · 2022Article
- Confrontment and solution to gonadotropin resistance and low oocyte retrieval in in vitro fertilization for type I BPES: a case series with review of literature.Journal of ovarian research · 2021Review
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundTo investigate the impact of follicular flushing on the number of oocytes retrieved and embryo quality and to determine the optimal number of flushings for poor ovarian responders (PORs) undergoing in vitro fertilization (IVF).
methodsThis retrospective study included 291 IVF cycles in 224 patients who were PORs and had no more than three dominant follicles on retrieval day. During oocyte retrieval, follicular fluid was aspirated and examined for an oocyte. If no oocyte was identified, follicular flushing was repeated until an oocyte was retrieved or up to a maximum of nine times.
resultsThe mean number of oocytes retrieved by aspiration and subsequent flushes was significantly higher than the number retrieved from the initial aspirate (1.73 ± 0.96 VS. 1.23 ± 1.00, P = 0.000). The total recovery rate was 83.7% (503/601), which was significantly higher than the 59.6% recovery rate for direct aspiration (P = 0.000). Before the 4th follicular flushing, the cumulative recovery rate increased significantly as flushing was repeated, but after the 4th flushing, the ascending trend was mitigated; and the risk ratio of recovering fewer oocytes after 4 flushes compared with after 9 flushes was 0.765 (95%CI, 0.570-1.026, P = 0.074). Significant differences were not observed in maturation rate, fertilization rate, cleavage rate or high-quality embryo rate (P > 0.05).
conclusionsFollicular flushing may increase the number of oocytes retrieved and does not have adverse effects on oocyte or embryo quality in PORs undergoing IVF. Four times may be an optimal number of follicular flushings.
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