Evidence map›Paper›PMID 30445747›Full record

ArticleMolecules (Basel, Switzerland)2018

QSAR and Molecular Docking Studies of the Inhibitory Activity of Novel Heterocyclic GABA Analogues over GABA-AT.

Josué Rodríguez-Lozada, Erika Tovar-Gudiño, Juan Alberto Guevara-Salazar, Rodrigo Said Razo-Hernández, Ángel Santiago, Nina Pastor, Mario Fernández-Zertuche

Open access · goldAbstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.0field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 11 citations in OpenAlex.

  1. Review
  2. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Josué Rodríguez-LozadaInstituto de Investigación en Ciencias Básicas y Aplicadas, Centro de Investigaciones Químicas, Universidad Autónoma del Estado de Morelos, 62209 Cuernavaca, Morelos, Mexico. jrl@uaem.mx.ORCID 0000-0001-8186-4772
Erika Tovar-GudiñoInstituto de Investigación en Ciencias Básicas y Aplicadas, Centro de Investigaciones Químicas, Universidad Autónoma del Estado de Morelos, 62209 Cuernavaca, Morelos, Mexico. egt@uaem.mx.
Juan Alberto Guevara-SalazarDepartmento de Bioquímica, Escuela Superior de Medicina, Instituto Politécnico Nacional, 11340 Cd México, Mexico. jguevaras@ipn.mx.
Rodrigo Said Razo-HernándezInstituto de Investigación en Ciencias Básicas y Aplicadas, Centro de Investigación en Dinámica Celular, Universidad Autónoma del Estado de Morelos, 62209 Cuernavaca, Morelos, Mexico. rodrigo.razo@uaem.mx.
Ángel SantiagoInstituto de Investigación en Ciencias Básicas y Aplicadas, Centro de Investigación en Dinámica Celular, Universidad Autónoma del Estado de Morelos, 62209 Cuernavaca, Morelos, Mexico. jast@uaem.mx.ORCID 0000-0002-3957-0970
Nina PastorInstituto de Investigación en Ciencias Básicas y Aplicadas, Centro de Investigación en Dinámica Celular, Universidad Autónoma del Estado de Morelos, 62209 Cuernavaca, Morelos, Mexico. nina@uaem.mx.ORCID 0000-0001-7755-2936
Mario Fernández-ZertucheInstituto de Investigación en Ciencias Básicas y Aplicadas, Centro de Investigaciones Químicas, Universidad Autónoma del Estado de Morelos, 62209 Cuernavaca, Morelos, Mexico. mfz@uaem.mx.ORCID 0000-0002-3165-9313
Universidad Autónoma del Estado de Morelos · MXInstituto Politécnico Nacional · MX

Funding

Consejo Nacional de Ciencia y Tecnología 241088
6 · The paper itself

Abstract

We have previously reported the synthesis, in vitro and in silico activities of new GABA analogues as inhibitors of the GABA-AT enzyme from

Indexed as

Molecular Docking SimulationMolecular Dynamics SimulationQuantitative Structure-Activity Relationship4-Aminobutyrate TransaminaseEnzyme Activationgamma-Aminobutyric AcidHumansLigandsMagnetic Resonance SpectroscopyMolecular StructurePseudomonas fluorescens4-Aminobutyrate Transaminasegamma-Aminobutyric AcidLigandsGABA-AT dockingGABA-AT enzymeheterocyclic GABA analoguesinhibitorsQSAR

Identifiers

PMID30445747
PMCPMC6278377
OpenAlexW2901613864

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.