Evidence map›Paper›PMID 30445732›Full record

ArticleViruses2018

Human Bocavirus Infection Markers in Peripheral Blood and Stool Samples of Children with Acute Gastroenteritis.

Zaiga Nora-Krukle, Anda Vilmane, Man Xu, Santa Rasa, Inga Ziemele, Elina Silina, Maria Söderlund-Venermo, Dace Gardovska, Modra Murovska

Open access · goldAbstract read
In one paragraph

Article in Viruses, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
1.5field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 22 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Molecular evidence of rat bocavirus among rodents in Peninsular Malaysia.The Journal of veterinary medical science · 2022
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 2 countries.

Zaiga Nora-KrukleInstitute of Microbiology and Virology, Rīga Stradiņš University, 5 Ratsupites St., LV-1067 Riga, Latvia. zaiga.nora@rsu.lv.ORCID 0000-0002-0594-1091
Anda VilmaneInstitute of Microbiology and Virology, Rīga Stradiņš University, 5 Ratsupites St., LV-1067 Riga, Latvia. anda.vilmane@rsu.lv.
Man XuDepartment of Virology, University of Helsinki, 3 (PL21), 00014 Helsinki, Finland. man.xu@helsinki.fi.
Santa RasaInstitute of Microbiology and Virology, Rīga Stradiņš University, 5 Ratsupites St., LV-1067 Riga, Latvia. santa.rasa@rsu.lv.ORCID 0000-0001-6519-7121
Inga ZiemeleChildren's Clinical University Hospital, 45 Vienibas Avenue, LV-1004 Riga, Latvia. inga.ziemele@gmail.com.
Elina SilinaDepartment of Paediatrics, Rīga Stradiņš University, 16 Dzirciema St., LV-1067 Riga, Latvia. sil.elina.23@gmail.com.
Maria Söderlund-VenermoDepartment of Virology, University of Helsinki, 3 (PL21), 00014 Helsinki, Finland. maria.soderlund-venermo@helsinki.fi.ORCID 0000-0002-4582-8317
Dace GardovskaChildren's Clinical University Hospital, 45 Vienibas Avenue, LV-1004 Riga, Latvia. dace.gardovska@rsu.lv.
Modra MurovskaInstitute of Microbiology and Virology, Rīga Stradiņš University, 5 Ratsupites St., LV-1067 Riga, Latvia. modra@latnet.lv.
Riga Stradiņš University · LVChildren's Clinical University Hospital · LVUniversity of Helsinki · FI

Funding

China Scholarship Council No numberLife and Health Medical Grant Association No numberNational Research Program "BIOMEDICINE" project No. 5.6.2Rīga Stradiņš University research project "Epidemiology, pathogenicity of human bocavirus (HBoV) types and their possible connection to lower respiratory tract diseases and acute gastroenteritis in children" RSU ZP 17/2013Seventh Framework Programme agreement number 316275Sigrid Jusélius Foundation No number
6 · The paper itself

Abstract

Human bocaviruses (HBoVs) 1⁻4 belong to the Parvoviridae family, and they infect the respiratory or gastrointestinal tracts in children. We investigated the prevalence of HBoV1⁻4 DNAs in the blood and stool samples, and of HBoV1⁻4 IgG and IgM in the plasma samples, of children presenting with acute gastroenteritis (AGE). In addition, we identified HBoV co-infections with the five most frequent gastrointestinal pathogens. A total of 83 paired blood and stool samples were collected from children aged five years or less. Infection markers of HBoV1, 2, or 3 (viral DNA in blood and/or stool and/or antibodies) were detected in 61 out of 83 (73.5%) patients. HBoV1, 2, or 3 DNA as a monoinfection was revealed in 18.1%, 2.4%, and 1.2%, respectively, and 21.7% in total. In 56.1% of the HBoV DNA-positive patients, the presence in stool of another virus-most frequently norovirus or rotavirus-was observed. In conclusion, this study, for the first time, illustrates the prevalence and genetic diversity of HBoVs in Latvian children with gastroenteritis, and shows a widespread distribution of these viruses in the community. HBoV1 and 2 are commonly found as single infectious agents in children with AGE, suggesting that the viruses can be as pathogenic by themselves as other enteric agents are.

Indexed as

Blood Chemical AnalysisAntibodies, ViralBiomarkersChildChild, PreschoolDNA, ViralFecesFemaleGastroenteritisHuman bocavirusHumansImmunoglobulin GImmunoglobulin MInfantInfant, NewbornMaleAntibodies, ViralBiomarkersDNA, ViralImmunoglobulin GImmunoglobulin Macute gastroenteritischildrenhuman bocavirus

Identifiers

PMID30445732
PMCPMC6265904
OpenAlexW2901393203

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.