ArticleNanomaterials (Basel, Switzerland)2018
Preparation of Hydrogen Peroxide Sensitive Nanofilms by a Layer-by-Layer Technique.
Article in Nanomaterials (Basel, Switzerland), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed, 4 citations in OpenAlex.
- Therapeutic impacts of GNE‑477‑loaded HInternational journal of molecular medicine · 2024Article
- Electrical Stimuli-Responsive Decomposition of Layer-by-Layer Films Composed of Polycations and TEMPO-Modified Poly(acrylic acid).Polymers · 2022Article
- Sequence Does Not Matter: The Biomedical Applications of DNA-Based Coatings and Cores.International journal of molecular sciences · 2021Review
- Decomposition of Glucose-Sensitive Layer-by-Layer Films Using Hemin, DNA, and Glucose Oxidase.Polymers · 2020Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
H₂O₂-sensitive nanofilms composed of DNA and hemin-appended poly(ethyleneimine) (H-PEI) were prepared by a layer-by-layer deposition of DNA and H-PEI through an electrostatic interaction. The (H-PEI/DNA)₅ film was decomposed by addition of 10 mM H₂O₂. H₂O₂-induced decomposition was also confirmed in the hemin-containing (PEI/DNA)₅ in which hemin molecules were adsorbed by a noncovalent bond to the nanofilm. On the other hand, the (PEI/DNA)₅ film containing no hemin and the (H-PEI/PSS)₅ film using PSS instead of DNA did not decompose even with 100 mM H₂O₂. The mechanism of nanofilm decomposition was thought that more reactive oxygen species (ROS) was formed by reaction of hemin and H₂O₂ and then the ROS caused DNA cleavage. As a result (H-PEI/DNA)₅ and hemin-containing (PEI/DNA)₅ films were decomposed. The decomposition rate of these nanofilms were depended on concentration of H₂O₂, modification ratio of hemin, pH, and ionic strength.
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Registered trials
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