Evidence map›Paper›PMID 30445703›Full record

ArticleNutrients2018

Does the Mediterranean Diet Protect against Stress-Induced Inflammatory Activation in European Adolescents? The HELENA Study.

Kenia M B Carvalho, Débora B Ronca, Nathalie Michels, Inge Huybrechts, Magdalena Cuenca-Garcia, Ascensión Marcos, Dénes Molnár, Jean Dallongeville, Yannis Manios, Beatriz D Schaan and 3 more

Open access · goldAbstract readMulticenter Study
In one paragraph

Article in Nutrients, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed, 1 pooled it
4.4field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 1 synthesis or guideline pooled it, 44 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Nutrients · 2023
    Trial
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  6. Biocontrol potential ofParasite epidemiology and control · 2025
    Article
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  12. Low-Grade Inflammation and Role of Anti-Inflammatory Diet in Childhood Obesity.International journal of environmental research and public health · 2023
    Review
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  15. Nurses' eating habits in Lebanon during the economic and health crises: a cross-sectional study.Archives of public health = Archives belges de sante publique · 2022
    Article
  16. Review
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  18. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 9 institutions in 7 countries.

Kenia M B CarvalhoGraduate Program in Human Nutrition, University of Brasília, Brasília 70910-900, Brazil. kenia@unb.br.ORCID 0000-0003-2799-1038
Débora B RoncaGraduate Program in Human Nutrition, University of Brasília, Brasília 70910-900, Brazil. deboraronca@gmail.com.
Nathalie MichelsDepartment of Public Health, Faculty of Medicine and Health Sciences, Ghent University, 9000 Ghent, Belgium. Nathalie.Michels@UGent.be.ORCID 0000-0002-3069-7254
Inge HuybrechtsDepartment of Public Health, Faculty of Medicine and Health Sciences, Ghent University, 9000 Ghent, Belgium. HuybrechtsI@iarc.fr.ORCID 0000-0003-3838-855X
Magdalena Cuenca-GarciaDepartment of Medical Physiology, School of Medicine, University of Granada, 18071 Granada, Spain. magdalena.cuenca@uca.es.
Ascensión MarcosICTAN-CSIC Spanish National Research Council, 28040 Madrid, Spain. amarcos@ictan.csic.es.
Dénes MolnárDepartment of Paediatrics, Medical School, University of Pécs, 7623 Pécs, Hungary. denes.molnar@aok.pte.hu.
Jean DallongevilleInstitut Pasteur de Lille, 59800 Lille, France. jean.dallongeville@pasteur-lille.fr.
Yannis ManiosDepartment of Nutrition and Dietetics, Harokopio University, 17671 Athens, Greece. helena@hua.gr.
Beatriz D SchaanGraduate Program in Medical-Sciences, Endocrinology, Federal University of Rio Grande do Sul, Porto Alegre 90035-003, Brazil. bschaan@hcpa.edu.br.
Luis MorenoGENUD (Growth, Exercise, Nutrition and Development) Research Group, 50013 Zaragoza, Spain. lmoreno@unizar.es.
Stefaan de HenauwDepartment of Public Health, Faculty of Medicine and Health Sciences, Ghent University, 9000 Ghent, Belgium. stefaan.dehenauw@ugent.be.
Livia A CarvalhoDepartment of Clinical Pharmacology, William Harvey Research Institute, Barts and The London Hospital, Queen Mary University of London, London E1 4NS, UK. l.carvalho@qmul.ac.uk.
Ghent University · BEUniversidade de Brasília · BRConsejo Superior de Investigaciones Científicas · ESHarokopio University of Athens · GRInstitut Pasteur de Lille · FRQueen Mary University of London · GBUniversidad de Granada · ESUniversidade Federal do Rio Grande do Sul · BRUniversity of Pecs · HU

Funding

World Health Organization 001
6 · The paper itself

Abstract

Stress increases inflammation but whether adherence to Mediterranean diet counteracts this association and how early can these effects be observed is not well known. We tested whether (1) cortisol is associated to inflammation, (2) cortisol is associated to the adolescent Mediterranean diet score (aMDS), (3) aMDS lessens inflammation, (4) aMDS associates with cortisol levels and inflammation. Two hundred and forty-two adolescents (137 females; 12.5⁻17.5 years old) provided salivary cortisol, blood and 2-day 24-h dietary recall from which aMDS was derived. Cortisol levels were associated with increased tumor necrosis factor (TNF-α

Indexed as

Diet, MediterraneanAdolescentBiomarkersChildDiet RecordsEuropeFemaleHumansHydrocortisoneInflammationInflammation MediatorsMaleProtective FactorsSalivaStress, PhysiologicalStress, PsychologicalBiomarkersHydrocortisoneInflammation MediatorsTumor Necrosis Factor-alphadepressive symptomsdiet qualityepidemiologyhypothalamic–pituitary–adrenal-HPA axisimmune systempreventionrisk factors

Identifiers

PMID30445703
PMCPMC6266959
OpenAlexW2901316001

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.