Evidence map›Paper›PMID 30445675›Full record

ArticleInsects2018

Pharmacological Inhibition of Inward Rectifier Potassium Channels Induces Lethality in Larval

Renata Rusconi Trigueros, Corey R Hopkins, Jerod S Denton, Peter M Piermarini

Open access · goldAbstract read
In one paragraph

Article in Insects, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.0field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 10 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 1 country.

Renata Rusconi TriguerosDepartment of Entomology, The Ohio State University, Ohio Agricultural Research and Development Center, Wooster, OH 44691, USA. renata.rusconi21@gmail.com.
Corey R HopkinsDepartment of Pharmaceutical Sciences, University of Nebraska Medical Center, Omaha, NE 68198, USA. corey.hopkins@unmc.edu.ORCID 0000-0003-4958-1697
Jerod S DentonDepartments of Anesthesiology and Pharmacology, Vanderbilt University Medical Center, Nashville, TN 37232, USA. jerod.s.denton@vumc.org.
Peter M PiermariniDepartment of Entomology, The Ohio State University, Ohio Agricultural Research and Development Center, Wooster, OH 44691, USA. piermarini.1@osu.edu.ORCID 0000-0003-1020-5774
The Ohio State University · USUniversity of Nebraska Medical Center · USVanderbilt University Medical Center · US

Funding

Development of small molecule mosquitocides for controlling the primary vector of Zika virus, Aedes aegyptiR21AI128418 · NIAID · OHIO STATE UNIVERSITY · PI DENTON, JEROD S., HOPKINS, COREY R. · 2017 to 2018
$448k
NIAID NIH HHS R21 AI128418NIH HHS R21AI128418
6 · The paper itself

Abstract

The inward rectifier potassium (Kir) channels play key roles in the physiology of mosquitoes and other insects. Our group, among others, previously demonstrated that small molecule inhibitors of Kir channels are promising lead molecules for developing new insecticides to control adult female mosquitoes. However, the potential use of Kir channel inhibitors as larvicidal agents is unknown. Here we tested the hypothesis that pharmacological inhibition of Kir channels in the larvae of

Indexed as

bariuminsecticideKir channelmosquitosmall moleculeVU041

Identifiers

PMID30445675
PMCPMC6315791
OpenAlexW2900941608

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.