ArticlePathogens and disease2018
Chlamydiae in human intestinal biopsy samples.
Article in Pathogens and disease, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 22 citations in OpenAlex.
- Prevalence and Tetracycline Susceptibility ofMicroorganisms · 2026Article
- Infection of human organoids supports an intestinal niche for Chlamydia trachomatis.PLoS pathogens · 2024Article
- Article
- Abundance and prevalence of ESBL coding genes in patients undergoing first line eradication therapy for Helicobacter pylori.PloS one · 2023Article
- Recent advances and public health implications for environmental exposure to Chlamydia abortus: from enzootic to zoonotic disease.Veterinary research · 2022Review
- Immunohistochemical detection of chlamydia trachomatis in sexually transmitted infectious proctitis.BMC gastroenterology · 2022Article
- A Diagnostic Survey of Aborted Equine Fetuses and Stillborn Premature Foals in Denmark.Frontiers in veterinary science · 2021Article
- Article
- Detection ofJournal of veterinary diagnostic investigation : official publication of the American Association of Veterinary Laboratory Diagnosticians, Inc · 2020Article
- First case of a natural infection in a domestic cat (Felis catus) with the canid heart worm Angiostrongylus vasorum.Veterinary parasitology, regional studies and reports · 2019Article
- Detection of Rectal Chlamydia trachomatis in Heterosexual Men Who Report Cunnilingus.Sexually transmitted diseases · 2019Article
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Chlamydia trachomatis is frequently detected in anorectal specimens from men and women. A recent hypothesis suggests that C. trachomatis is a natural commensal organism asymptomatically colonizing the gastrointestinal tract. In this study, we investigated the presence of chlamydial DNA and antigen in intestinal biopsy samples taken during colonoscopy. Cases (n = 32) were patients whose histopathology reports included the term 'chlamydia', suggesting a possible history of infection. Control patients (n = 234) did not have chlamydia mentioned in their histopathology report and all tested negative for Chlamydiaceae DNA by 23S ribosomal RNA-based real-time PCR. Amongst the cases, C. trachomatis DNA was detected in the appendix and colon of two female and one male patients. Chlamydia abortus DNA was present in the colon of a fourth female patient. Thus, chlamydial DNA could be demonstrated in intestinal biopsy samples proximal to the anorectal site and inclusions were identified in rectum or appendix of two of these patients by immunohistochemistry. However, the findings in two cases were compatible with sexually acquired C. trachomatis. The identification of C. trachomatis DNA/antigen does not prove the presence of active infection with replicating bacteria. Larger prospective studies on fresh tissue samples are required to confirm the data obtained in this study.
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