Evidence map›Paper›PMID 30445275›Full record

Trial reportDrug and alcohol dependence2019

Effects of time-varying changes in tobacco and alcohol use on depressive symptoms following pharmaco-behavioral treatment for smoking and heavy drinking.

William V Lechner, Natasha K Sidhu, Patricia A Cioe, Christopher W Kahler

Abstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Drug and alcohol dependence, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Smoking cessation for improving mental health.The Cochrane database of systematic reviews · 2021
    Pooled it
  3. Trial
  4. Article
  5. Article
  6. Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

William V LechnerDepartment of Psychological Sciences, Kent State University, 144 Kent Hall, P.O. Box 5190, Kent, OH, 44242-0001, USA; Center for Alcohol and Addiction Studies, Brown University School of Public Health, 121 South Main Street, Box G-S121-5, Providence, RI, USA. Electronic address: wlechner@kent.edu.
Natasha K SidhuDepartment of Psychological Sciences, Kent State University, 144 Kent Hall, P.O. Box 5190, Kent, OH, 44242-0001, USA.
Patricia A CioeCenter for Alcohol and Addiction Studies, Brown University School of Public Health, 121 South Main Street, Box G-S121-5, Providence, RI, USA.
Christopher W KahlerCenter for Alcohol and Addiction Studies, Brown University School of Public Health, 121 South Main Street, Box G-S121-5, Providence, RI, USA.

Funding

Naltrexone for At-Risk and Problem Drinking in Smoking Cessation TreatmentR01AA017181 · NIAAA · BROWN UNIVERSITY · PI KAHLER, CHRISTOPHER W. · 2009 to 2013
$3.0M
Working Memory Training Combined with Repetitive Transcranial Magnetic Stimulation in SmokersR21DA042989 · NIDA · KENT STATE UNIVERSITY · PI LECHNER, WILLIAM V., PHILIP, NOAH STEPHEN · 2017 to 2018
$431k
Cardiovascular Risk Perception and Wellness Perspectives in HIV-infected AdultsK23NR014951 · NINR · BROWN UNIVERSITY · PI CIOE, PATRICIA ANN · 2014 to 2016
$397k
NIAAA NIH HHS R01 AA017181NIDA NIH HHS L30 DA042426NIDA NIH HHS R21 DA042989NINR NIH HHS K23 NR014951
6 · The paper itself

Abstract

backgroundComplete abstinence from alcohol as well as smoking cessation have been shown to predict reductions in depressive symptoms over time. However, whether reducing alcohol use or smoking positively affect depressive symptoms has yet to be examined. The current study examined depressive symptoms as a function of time-varying changes in alcohol use and smoking status following a pharmaco-behavioral treatment addressing smoking cessation and alcohol reduction.

methodsParticipants were heavy-drinking smokers (n = 150) followed for 26 weeks after their quit smoking date, with assessments of smoking, alcohol use, and depressive symptoms at baseline and 2, 8, 16, and 26 weeks.

resultsAbstinence from smoking was associated with significantly lower depressive symptoms, as compared to little to no reduction in smoking (B = -6.1) as well as significant reductions in smoking (B = 4.01). Exploratory analyses, which excluded observations in which a participant was abstinent, revealed a significant effect of percent change in cigarettes smoked, modeled continuously, on depressive symptoms, (B = 4.39). By contrast, no differences were observed in depressive symptoms in relation to changes in alcohol use.

conclusionIt appears that smoking abstinence is associated with improvements in depression as compared to any level of sustained or reduced use and that the magnitude of smoking reduction may be associated with lower depressive symptoms among those who did not quit successfully. If replicated, these findings may inform treatment for individuals for whom depression is a major barrier to cessation and who have been unable or are unwilling to be completely abstinent from smoking.

Indexed as

AdultAlcohol DeterrentsAlcohol DrinkingBehavior TherapyDepressionFemaleHumansMaleMiddle AgedNaltrexoneSmoking CessationTime FactorsTobacco SmokingTobacco Use DisorderAlcohol DeterrentsNaltrexoneAbstinenceAlcoholDepressionNicotineSmokingSmoking cessation

Identifiers

PMID30445275
PMCPMC7364819

What OpenQuestion holds

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LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.